学位

• 博士（理学）(東京大学)

経歴

学歴

受賞

その他

論文

• Modular organization of synapses within a neuromere for distinct axial locomotion inDrosophilalarvae [DOI] [Othres link] [ResearchMap] [ResearchMap] [ResearchMap] [ResearchMap]
• Linking neural circuits to the mechanics of animal behavior in Drosophila larval locomotion [DOI] [Othres link]
• Synchronous multi-segmental activity between metachronal waves controls locomotion speed in Drosophila larvae [DOI] [Othres link] [Othres link]
• A vacuum-actuated soft robot inspired by Drosophila larvae to study kinetics of crawling behaviour [DOI] [Othres link]
• Extraction of bouton-like structures from neuropil calcium imaging data [DOI]
• Electrophysiological validation of monosynaptic connectivity between premotor interneurons and the aCC motoneuron in the Drosophila larval CNS. [DOI] [PubMed]
• A neuromechanical model for Drosophila larval crawling based on physical measurements. [DOI] [PubMed] [PubMed Central]
• Regulation of coordinated muscular relaxation in Drosophila larvae by a pattern-regulating intersegmental circuit [DOI] [PubMed] [PubMed Central] [Othres link] [Othres link]
• Interspecies variation of larval locomotion kinematics in the genus Drosophila and its relation to habitat temperature. [DOI] [PubMed] [PubMed Central]
• Optogenetics in Drosophila. [DOI] [PubMed]
• Technical Note: Interneurons for Specific Animal Behavior [DOI]
• Regulation of forward and backward locomotion through intersegmental feedback circuits in Drosophila larvae. [DOI] [PubMed] [PubMed Central]
• System level analysis of motor-related neural activities in larval Drosophila [DOI] [PubMed]
• Data-driven analysis of motor activity implicates 5-HT2A neurons in backward locomotion of larval Drosophila. [DOI] [PubMed] [PubMed Central] [Othres link] [Othres link]
• Divergent Connectivity of Homologous Command-like Neurons Mediates Segment-Specific Touch Responses in Drosophila [DOI] [PubMed] [Web of Scientce] [Othres link]
• Gap Junction-Mediated Signaling from Motor Neurons Regulates Motor Generation in the Central Circuits of Larval Drosophila [DOI] [PubMed] [PubMed Central] [Web of Scientce] [Othres link]
• Neural Circuits Underlying Fly Larval Locomotion [DOI] [PubMed] [PubMed Central] [Web of Scientce] [Othres link] [Othres link]
• Functional dissociation in sweet taste receptor neurons between and within taste organs of Drosophila [DOI] [PubMed] [PubMed Central] [Web of Scientce]
• A circuit mechanism for the propagation of waves of muscle contraction in Drosophila [DOI] [PubMed] [PubMed Central] [Web of Scientce] [Othres link] [Othres link]
• Functional dissociation in sweet taste receptor neurons between and within taste organs of Drosophila [DOI] [Web of Scientce] [Othres link] [Othres link]
• Identification of Inhibitory Premotor Interneurons Activated at a Late Phase in a Motor Cycle during Drosophila Larval Locomotion [DOI] [PubMed] [PubMed Central] [Web of Scientce] [Othres link] [Othres link]
• Optogenetics in Drosophila [DOI]
• A Group of Segmental Premotor Interneurons Regulates the Speed of Axial Locomotion in Drosophila Larvae [DOI] [PubMed] [Web of Scientce] [Othres link]
• Serotonin and Downstream Leucokinin Neurons Modulate Larval Turning Behavior in Drosophila [DOI] [Web of Scientce] [Othres link]
• Serotonin and Downstream Leucokinin Neurons Modulate Larval Turning Behavior in Drosophila [DOI] [PubMed] [PubMed Central] [Web of Scientce]
• Optogenetic perturbation of neural activity with laser illumination in semi-intact drosophila larvae in motion. [DOI] [PubMed] [PubMed Central] [Othres link] [Othres link]
• Role of Sensory Experience in Functional Development of Drosophila Motor Circuits [DOI] [PubMed] [PubMed Central] [Web of Scientce]
• Role of sensory experience in functional development of Drosophila motor circuits [DOI] [PubMed] [Web of Scientce] [Othres link] [Othres link]
• Development of larval motor circuits in Drosophila [DOI] [PubMed] [Web of Scientce]
• Development of larval motor circuits in Drosophila [DOI] [PubMed] [Web of Scientce] [Othres link]
• Optical Dissection of Neural Circuits Responsible for Drosophila Larval Locomotion with Halorhodopsin [DOI] [PubMed] [PubMed Central] [Web of Scientce] [Othres link] [Othres link]
• Target recognition at the tips of postsynaptic filopodia: accumulation and function of Capricious [DOI] [PubMed] [Web of Scientce] [Othres link] [Othres link]
• 3P-233 ぜん動運動を制御する神経回路の形成と可塑性の解析(神経回路・脳の情報処理,第46回日本生物物理学会年会) [DOI] [CiNii Research (CiNii Articles)]
• Innervation and activity dependent dynamics of postsynaptic oxidative metabolism [DOI] [Othres link] [Othres link]
• In vivo induction of postsynaptic molecular assembly by the cell adhesion molecule Fasciclin2 [PubMed] [PubMed Central] [CiNii Research (CiNii Articles)] [DOI] [Web of Scientce] [Othres link] [Othres link]
• S1g1-2 Dynamism and regulation of synaptic assembly at the neuromuscular junction in Drosophila(S1-g1: "Molecular Mechanisms of Axon Targeting and Synaptogensis",Symposia,Abstract,Meeting Program of EABS & BSJ 2006) [DOI] [CiNii Research (CiNii Articles)]
• 1M1045 シナプス形成初期における標的認識分子カプリシャスの可視化(15.神経・感覚,一般演題,日本生物物理学会第40回年会) [DOI] [CiNii Research (CiNii Articles)]

その他業績

• 複数の運動出力パターンを生み出す神経ネットワーク構造
• 【細胞多様性解明に資する光技術-見て,動かす】狙ったものを動かす 光によるショウジョウバエ中枢回路の機能解剖 [医中誌Web]
• Dissecting neural network with visible light and genetics [Web of Scientce]
• ショウジョウバエを用いたオプトジェネティクス研究（分担執筆）
• Formation and plastic change of the terminals of sensory feedback neurons involved in Drosophila larval locomotion [DOI] [Web of Scientce]
• Search for interneurons that regulate larval locomotion in Drosophila [DOI] [Web of Scientce]
• Identification of segmentally-arrayed interneurons that regulate larval locomotion in Drosophila [DOI] [Web of Scientce]
• Imaging activity propagation in the larval motor circuits that regulate peristalsis [Web of Scientce]
• Temporal perturbation of neural activity in Drosophila larvae undergoing locomotion [DOI] [Web of Scientce]
• Functional localization of neuronal components controlling larval peristaltic movements in Drosophila [DOI] [Web of Scientce]
• Imaging activity propagation in the Drosophila motor circuits that regulate larval peristalsis [DOI] [Web of Scientce]
• 研究ニュース [CiNii Research (CiNii Articles)] [CiNii Books] [Othres link]
• Formation and plasticity of motor circuits in Drosophila [DOI] [Web of Scientce]
• Imaging of activity propagation in the nerve cord of Drosophila larvae [DOI] [Web of Scientce]
• Dynamisms of postsynaptic filopodia during target recognition of Drosophila Neuromuscular Junction [Web of Scientce]
• 【神経回路の制御と脳機能発現のメカニズム 細胞移動・接着から記憶・学習・行動発現までの分子基盤解明と研究を躍進させる最新技術】神経回路研究に利用される技術 シナプス形成過程の生体内可視化 [医中誌Web]
• Dynamics of postsynaptic filopodia in target recognition of Drosophila neuromuscular synaptogenesis [Web of Scientce]
• Postsynaptic accumulation of cell adhesion molecules imaged in vivo [Web of Scientce]
• Initial molecular steps in synaptogenesis in vivo: trans-synaptic interaction of cell adhesion molecule is involved in postsynaptic assembly of PSD95-homolog Dlg [Web of Scientce]
• 【脳の発生分化と回路形成】神経筋連絡の特異性を制御する分子機構 [医中誌Web] [医中誌Web]
• 神経筋シナプス形成過程における標的認識分子の動態観察 (日本顕微鏡学会第48回シンポジウム 材料科学と生命科学のクロストーク--顕微解析の最前線) -- (生物系セッション2 分子可視化技術による神経細胞の機能解析) [CiNii Research (CiNii Articles)] [CiNii Books] [Othres link]

講演・口頭発表等

• A higher-order interneuron that orchestrates intersegmental coordination in axial locomotion [ResearchMap] [ResearchMap] [ResearchMap]
• Interspecific comparison of fly larval movement [ResearchMap] [ResearchMap] [ResearchMap]
• 超音波による音響放射圧を用いたショウジョウバエ幼虫への適応的遠隔行動介入 [ResearchMap] [ResearchMap] [ResearchMap]
• ショウジョウバエ幼虫における持続的活動を示す神経細胞による運動出力のゲート制御 [ResearchMap] [ResearchMap] [ResearchMap]
• 軸性運動においてセグメント間協調を指揮する高次介在ニューロン
• Transient suppression of tonically active neurons gates motor output in Drosophila larval crawling [ResearchMap] [ResearchMap]
• Identification of a novel interneuron that regulates forward wave propagation in Drosophila larvae [ResearchMap] [ResearchMap]
• A tonically active neuron implicated in the maintenance of muscle relaxation in Drosophila larvae [ResearchMap] [ResearchMap]
• Neural circuits and mechanics for crawling in fruit fly larvae
• Two perpendicular stripe-wise structures in the neuropil involved in generation of Drosophila larval crawling behaviors
• Revealing behavior-specific neuronal populations in Drosophila larvae with a photoconvertible calcium sensor
• Mechanisms of neural circuit reorganization that enable coordinated movement
• Spatiotemporal structure of synapse population activity in the motor circuits for crawling
• Synchronous multi-segmental activity between metachronal waves controls the crawling speed in fly larvae
• Synchronous multi-segmental activity controls the speed of axial locomotion by modulating the interval between peristaltic waves in Drosophila larvae
• Autonomous learning of technical vocabulary used in computer and information science for Japanese university students
• Automated real-time quantitative analysis of behavior in Drosophila larvae
• Comprehensive characterization of the axon bundles in the Drosophila larval motor circuits with expansion microscopy
• RNAi-based screening of neuromodulators involved in motor patterns of foraging behavior in Drosophila larvae
• Automated real-time quantitative analysis of behavior in Drosophila larvae
• Module structures in spatial distribution of activity timing and transmitters of synapse population in motor generating circuits
• ショウジョウバエ近縁種における幼虫運動制御の種間比較
• Dissecting the central nervous system in Drosophila larvae with expansion microscopy
• Spatial configuration of synapse population activities underlying the generation of larval motor patterns
• Quantitative analysis of Drosophila larval locomotion based on machine vision

書籍等出版物

• Optogenetics 2nd edition

作品等

共同研究・競争的資金等の研究課題

• 遠隔触覚刺激・二次元通信を用いた行動介入基盤の開発と行動予測に基づく動作解析
• In toto イメージングによる運動制御神経回路の構築過程の解明
• スムーズな筋収縮パターンを生み出す運動制御神経回路機構の解明
• 同一の神経回路網が相異なる運動出力を生み出すネットワーク機構の解明
• 時空間パターンを生み出すメゾ回路の作動原理の解明
• 環境に適応した運動出力を生み出す神経回路機構の解明
• 運動出力の時空間パターンを生み出す神経回路基盤の解明
• 局所神経回路形成による運動機能獲得過程の解明
• 特異的シナプス形成過程に関与する分子の同定と動態観察
• ショウジョウバエ神経筋結合系を用いたシナプス形成初期過程の解析

メディア報道

• 電通大と東大、ハエの幼虫において運動と運動の間の静止時に特定の筋が収縮していることを発見(日本経済新聞・電子版)
• ロボットの応用領域広がる・柔軟に動くソフトロボ()
• 虫のような軟らかいロボット、電通大ら開発 電子回路など微細環境での作業の応用期待(Yahoo! JAPAN ニュース)
• 電通大と東大、しなやかな幼虫の動きを再現するソフトロボットの開発に成功(日本経済新聞・電子版)
• 虫のような軟らかいロボット、電通大ら開発 電子回路など微細環境での作業の応用期待(電波新聞・電子版)
• Extraction of bouton-like structures from neuropil calcium imaging data(AAAS (American Association for the Advancement of Science))
• 電通大と東大、物性測定に基づいた虫の動きの神経力学モデルを構築し高精度なシミュレーションに成功(日本経済新聞・電子版)
• Relationship between the speed at which insects move and the environmental temperature(UEC e-Bulletin)
• ショウジョウバエ幼虫 移動速度が気温と相関(科学新聞)
• 電通大など、虫の動き方と気候の相関関係を解明(国立環境研究所)

産業財産権

所属学協会

委員歴

担当経験のある科目

• Technical English － Basic English for Science
• 物理学実験・エレクトロニクス
• 複雑生命現象論
• 非線形システム解析論
• 実験概論
• Neural circuits
• 神経回路学
• Graduate Technical English
• 大学院技術英語
• Academic English for the Second Year I
• Academic English for the Second Year I
• Academic Written English I
• Academic Written English I
• 英語演習
• 英語演習
• Academic English for the Second Year II
• Academic English for the Second Year II
• Academic Spoken English II
• Academic Spoken English II
• Academic Written English II
• Academic Written English II

社会貢献活動

• 研究成果の公開 【ニュースリリース】ぜん動運動の静止時間により運動速度が変化 ー ソフトロボティクスなどへの応用に期待 ー
• 研究成果の公開 【ニュースリリース】しなやかな幼虫の動きを再現するソフトロボットの開発に成功 ー ぜん動運動の物理の解明に貢献 ー

学術貢献活動