学位

• 理学博士（名古屋大学 1979-03）
• Ph. D（Nagoya University）

経歴

学歴

受賞

• 有機合成化学奨励賞（有機合成化学協会）（1987-02）

その他

論文

• Toward bioluminescence in the near-infrared region: Tuning the emission wavelength of firefly luciferin analogues by allyl substitution（2018-03-21） [DOI]
• Aspiration Risk Detection Using Oral Administration of Fluorescent Food --- Preliminary Experiments Using Meat Phantoms ---（2017-10-17）
• A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging.（2016-06-14） [DOI] [PubMed] [PubMed Central]
• Synthesis and evaluation of new firefly luciferin analogues for luminescent materials（2016）
• "Synthesis and evaluation of the luminescent properties of firefly luciferin analogues "（2016）
• Spectroscopic properties of BF2 complexes of N-(5-phenyl-2- pyrazinyl)pivalamides exhibiting fluorescence in solution and solid state (http://dx.doi.org/10.1016/j.jphotochem.2015.10.014)（2016）
• Multicolor Bioluminescence Obtained Using Firefly Luciferin（2016） [DOI] [Web of Scientce]
• Fluorescence Properties of Diphenylthiazolo[4,5-b]pyrazines Tuned by Donor-Acceptor Substituent Effects（2015-07） [DOI] [Web of Scientce]
• Synthesis and chemiluminescent properties of 6,8-diaryl-2-methylimidazo[1,2-alpha]pyrazin-3(7H)-ones: Systematic investigation of substituent effect at para-position of phenyl group at 8-position（2014-11） [DOI] [Web of Scientce]
• Substituent effects on fluorescence properties of thiazolo[4,5-b]pyrazine derivatives（2014） [DOI] [Web of Scientce]
• Synthesis and luminescence properties of biphenyl-type firefly luciferin analogs with a new, near-infrared light-emitting bioluminophore（2013-11） [DOI] [Web of Scientce]
• Development of simple firefly luciferin analogs emitting blue, green, red, and near-infrared biological window light（2013-05-13） [DOI]
• Evaluation of Bioluminescence Activity of Firefly Luciferin Nucleotide Derivatives（2013）
• 5-[4-(Dimethylamino)phenyl]-2-benzamidopyrazines: fluorescent dyes based on Cypridina oxyluciferin（2013-01） [DOI] [Web of Scientce]
• Anoikis Induction and Inhibition of Peritoneal Metastasis of Pancreatic Cancer Cells by a Nuclear Factor-kappa B Inhibitor, (-)-DHMEQ（2013） [DOI] [Web of Scientce]
• Spectroscopic studies of the color modulation mechanism of firefly (beetle) bioluminescence with amino-analogs of luciferin and oxyluciferin（2012-08） [DOI]
• Studies on (-) ESIMS/MS of a glycosaminoglycan disaccharide N-acetyllactosamine-6, 6’-disulfate disodium salt---Charge-localization isomers.（2012-02） [DOI] [Web of Scientce]
• Spectroscopic studies of the color modulation mechanism of firefly (beetle) bioluminescence with amino-analogs of luciferin and oxyluciferin（2012） [DOI] [Web of Scientce]
• Bioluminescence characteristics of the fruiting body of Mycena chlorophos（2011-11） [DOI] [Web of Scientce]
• Influence of Electron-Donating and Electron-Withdrawing Substituents on the Chemiluminescence Behavior of Coelenterazine Analogs（2011-01） [DOI]
• Influence of Electron-Donating and Electron-Withdrawing Substituents on the Chemiluminescence Behavior of Coelenterazine Analogs（2011-01） [DOI] [Web of Scientce]
• Colorimetric and fluorometric sensing of the Lewis acidity of a metal ion by metal-ion complexation of imidazo[1,2-a]pyrazin-3(7H)-ones（2010-05） [DOI] [Web of Scientce]
• Synthesis and properties of bis(pyrazino[2 ',3 ':4,5]imidazole)-fused 1,2,5,6-tetrahydro-1,4,5,8,9,10-hexaazaanthracenes: a new fluorescent nitrogen-rich heterocycle（2010-03） [DOI] [Web of Scientce]
• Synthesis and fluorescence properties of difluoro[amidopyrazinato-O,N]boron derivatives: a new boron-containing fluorophore（2010-03） [DOI] [Web of Scientce]
• Distinction of Sialyl Anomers on ESI- and FAB-MS/MS: Stereo-Specific Fragmentations（2009-03） [DOI] [Web of Scientce]
• Spectroscopic Studies of the Light-Color Modulation Mechanism of Firefly (Beetle) Bioluminescence（2009-02） [DOI] [Web of Scientce]
• CHEMIEXCITATION MECHANISM FOR CYPRIDINA (VARGULA) AND AEQUOREA BIOLUMINESCENCE（2009） [Web of Scientce]
• The reaction mechanism for the high quantum yield of Cypridina (Vargula) bioluminescence supported by the chemiluminescence of 6-aryl-2-methylimidazo[1,2-a]pyrazin-3(7H)-ones (Cypridina luciferin analogues)（2008） [DOI] [Web of Scientce]
• Electrolysis and its hybrid methods applied to decomposition of endocrine disrupting chemicals（2006-08） [Web of Scientce]
• Chemiluminescence of 6-aryl-2-methylimidazo[1,2-a]pyrazin-3(7H)-ones in DMSO/TMG and in diglyme/acetate buffer: support for the chemiexcitation process to generate the singlet-excited state of neutral oxyluciferin in a high quantum yield in the Cypridina (Vargula) bioluminescence mechanism（2006-08） [DOI] [Web of Scientce]
• Real light emitter in the bioluminescence of the calcium-activated photoproteins aequorin and obelin: light emission from the singlet-excited state of coelenteramide phenolate anion in a contact ion pair（2006-06） [DOI] [Web of Scientce]
• Construction of a New Firefly Bioluminescence System using L-luciferin（2006）
• Substituent effects on the kinetics for the chemiluminescence reaction of 6-arylimidazo[1,2-a]pyrazin-3(7H)-ones (Cypridina luciferin analogues): support for the single electron transfer (SET)–oxygenation mechanism with triplet molecular oxyg（2005-11） [DOI] [Web of Scientce]
• Substituent effects on the spectroscopic properties of solvatochromic 2-phenylimidazo[1,2-a]pyrazin-3(7H)-ones: an effective control for the colorimetric sensor properties（2005-10） [DOI] [Web of Scientce]
• Bioluminescence in the limpet-like snail Latia neritoides.（2005-07）
• Firefly luciferase exhibits bimodal action depending on the luciferin chirality（2005-06） [DOI] [Web of Scientce]
• Electron-transfer oxygenation mechanism in the chemiluminescence reaction of imidazo[1,2-a]pyrazin-3(7H)-one with triplet dioxygen（2005）
• Characterization of [1-13C]-Specifically Labeled Amino Acids Using ESIMS/MS in the Selected Reaction Monitoring Mode（2005）
• 6,8-diarylimbazo[1, 2-a]pyrazin-3(7H) - Ones as potential chemiluminescent pH/superoxide double sensors（2005） [Web of Scientce]
• Development of the chemistry of the imidazopyrazionone-bioluminescence system: From the bio- and chemiluminescence mechanism to a design of sensor molecules（2005） [Web of Scientce]
• Bioluminescence activity of Latia luciferin analogues: replacement of the 2,6,6-trimethylcyclohexene ring onto the methyl-substituted phenyl groups（2005-01） [DOI] [Web of Scientce]
• Characterization of Regio-specific 13CO-Labeling of Amino Acids Using ESIMS/MS in the SRM Mode.（2005）
• Substituent effects on the solvatochromism of 2-phenylimidazopyrazinones: Effective control of the color variation range and sensitivity toward an indication of the proton-donor ability of solvents by an electron-withdrawing group substitution（2004-11） [DOI] [Web of Scientce]
• Regioselective phenyl-substitution effects on the solvatochromism of 2-phenylimidazo[1,2-a]pyrazin-3(7H)-one derivatives: Expansion of the color variation range of a visible indicator for the proton donor ability of solvents.（2004-10）
• Synthesis of prostaglandin F ethanolamide by prostaglandin F synthase and identification of Bimatoprost as a potent inhibitor of the enzyme: new enzyme assay method using LC/ESI/MS（2004-04） [DOI] [Web of Scientce]
• Synthesis of Latia Luciferin Benzoate Analogues and those Bioluminescent Activity.（2004-02）
• Analysis of sugar epimers using mass spectrometry: N-acetyllactosamine-6,6 '-disulfate and the 2 '-epimer（2004） [DOI] [Web of Scientce]
• Metal-ion complexation of imidazo[1,2-a]pyrazin-3(7H)-ones: continuous changes in absorption spectra of complexes depending on the Lewis acidity of the metal ion（2004-01） [DOI] [Web of Scientce]
• Fundamental studies on the structures and spectroscopic properties of imidazo[1,2-a]pyrazin-3(7H)-one derivatives（2003-12） [DOI] [Web of Scientce]
• Essential (110)Cys in active site of membrane-associated prostaglandin E synthase-2（2003-06） [DOI] [Web of Scientce]
• Pd black deposited on polypropylene sheet as a highly selective catalyst for hydrogenation of alkenes（2003-04） [DOI] [Web of Scientce]
• Hydrogenolysis-free Hydrogenation Using Pd Black Catalyst Deposited on Pd Sheet.（2003）
• Viscosity-dependent fluorescence decay of the GFP chromophore in solution due to fast internal conversion（2002-08） [DOI] [Web of Scientce]
• Preparation of Deoxygenated Derivatives of Neoanisatin, a Neurotoxic Sesquiterpenoid Having a β-Lactone.（2002-02） [Web of Scientce]
• Reduction in Desorption Mass Spectrometry: Multiple Protonation on Flavins without Charge Increment.（2002）
• Preparation and Toxic Property of Carbapicrotoxinin, a Cyclopropane-containing Analog of a GABA-antagonistic Sesquiterpenoid Picrotoxinin.（2002）
• Fluorescence properties of phenolate anions of coelenteramide analogues: the light-emitter structure in aequorin bioluminescence（2001-12） [Web of Scientce]
• Effect of solvent and hydrogen during selective hydrogenation（2001-11） [Web of Scientce]
• Hydrogenolysis-free hydrogenation by Pd black powder catalyst（2001-10） [Web of Scientce]
• Purification and Properties of the Luciferase from the Marine Ostracod Vargula hilgendorfii.（2001）
• Improved Syntheses of Watasenia Preluciferin (Coelenterazine) and Watasenia Luciferin (Coelenterazine Disulfate), and Site Specific Syntheses of the Coelenterazine Monosulfates.（2001）
• Intramolecular electron-transfer-induced cleavage of dioxetanes observed in fast-atom bombardment tandem mass spectrometry（2001） [Web of Scientce]
• Isoquinoline formation by a novel photochemical intermolecular cycloaddition of 1,1-diphenylethene derivatives to 1,4-dicyanobenzene（2000-08） [Web of Scientce]
• 2,3,3a,4,9,9a-Hexahydro-9-phenyl-benzo[f]indene derivatives（2000-07） [Web of Scientce]
• Bioluminescence activity of Latia luciferin analogs（2000-06） [Web of Scientce]
• Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using an inorganic particle matrix for small molecule analysis（2000-03） [Web of Scientce]
• Synthesis, chemi- and bioluminescence properties, and photolysis of a coelenterazine analogue having a photoreactive azido group（2000-02） [DOI]
• Synthesis and Chemi-and Bio-luminescence Properties of a Photolabile Coelenterazine Analogue Bearing an Azido Group.（2000）
• Differentiation Between N-Acetylchondrosine and N-Acetyldermosin by Matrix-assisted Laser Desorption Ionization Time-of-flight Post Source Decay Mass Spectrometry.（2000）
• Phosphopeptide sequencing by in-source decay spectrum in delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry（2000-01） [Web of Scientce]
• Selective alkene hydrogenation with atomic hydrogen permeating through a Pd sheet electrode（2000） [Web of Scientce]
• Purification and Chracteristic Properties of the Luciferase from the Marine Ostracod Vargula hilgendorfii.（2000）
• Reactivity and pi-facial selectivity of nucleophile addition to the radical cations of 7-benzhydrylidenenorbornene derivatives（1999-01） [Web of Scientce]
• Regiocontrolled construction of functionalized spiro[4,4]nonanones through mercury(II) salt-assisted and acid-induced spiroannulation reactions（1999） [Web of Scientce]
• Stereoselective tandem cyclization of 1,1-diphenyl-1,n-alkadienes via photoinduced electron transfer reaction（1998-12） [Web of Scientce]
• Synthesis of(±)-Isoitalicene using Electrolysis under Irradiation as a Key Step.（1998-12） [Web of Scientce]
• Synthesis of dimethyl gloiosiphone A（1998-12） [Web of Scientce]
• Bioluminescent properties of fluorinated semi-synthetic aequorins（1998-07-30） [DOI]
• A novel, stereoselective photo-Ritter reaction of 1,1-diphenyl-1,6-heptadiene via photoindnced electron transfer reaction（1998-04） [Web of Scientce]
• "Fluorescent Properties of Model Chromophores of Tyrosine-66 Substituted Mutants of Aequorea Green Fluorescent Protein(GFP)"（1998）
• Substituent effects on the chemiluminescent properties of coelenterazine analogues（1998） [Web of Scientce]
• FAB-CID Mass Spectrometry of Imizdazplone DErivatives Related to the Chromophore of Green Fluorescent Potein in Jellyfish Bioluminescence.（1998）
• Fluorescent Properties of Model Chromophores for the Mutant Proteins of Aequorea Green Fluorescent Protein(GFP).（1998）
• Bioluminescent Properties of Fluorinated Semi-synthetic Aequorins : Structure Elucidation of the Light-emitter in Aequorin Bioluminescence.（1998）
• FAB CID-MS/MS of In-source Fragment Ions as a Means to Differenciate Linkage Isomers of Branched Sugars : Le＾a＾ and Le＾x ＾Type Glycoconjugates.（1998） [DOI] [CiNii Research (CiNii Articles)] [CiNii Books] [Othres link] [Othres link]
• Novel dehydration reaction of neoanisatin and transformation of neoanisatin into anisatin（1997-12） [Web of Scientce]
• Facile cleavage reactions of styrylic olefins using electrochemical methods（1997-12） [Web of Scientce]
• An efficient synthesis of racemic necine bases from a common intermediate（1997-10） [Web of Scientce]
• Solvent and substituent effects on the fluorescent properties of coelenteramide analogues（1997-09） [Web of Scientce]
• Abnormal reactivity of anisatin and neoanisatin to samarium iodide hexamethylphosphorictriamide（1997-06） [Web of Scientce]
• Mechanism of the redox reaction of the Aequorea green fluorescent protein (GFP)（1997-04） [Web of Scientce]
• Aequorea green fluorescent protein: Structural elucidation of the chromophore（1997） [Web of Scientce]
• Chemical nature of the light emitter of the Aequorea green fluorescent protein（1996-11） [Web of Scientce]
• Unusual reactions of C-60 with aldehydes in the presence of aqueous ammonia（1996-06） [Web of Scientce]
• A POTENTIAL PHOTOAFFINITY PROBE FOR LABELING THE ACTIVE-SITE OF AEQUORIN - A PHOTOLABILE COELENTERAZINE ANALOG WITH A TRIFLUOROMETHYLDIAZIRINE GROUP（1995-09） [Web of Scientce]
• ENANTIOSELECTIVE SYNTHESIS OF THE MACROCYCLIC PYRROLIZIDINE ALKALOID YAMATAIMINE（1994-11） [Web of Scientce]
• An Improved Syntheis of(±)-Otonecine and a Synthesis of a 12-Memebered Otonecine Diester.（1994-08） [Web of Scientce]
• A SYNTHESIS OF SENECIONINE, A REPRESENTATIVE OF HEPATOTOXIC, MACROCYCLIC PYRROLIZIDINE ALKALOIDS OF RETRONECINE TYPE（1994-07） [Web of Scientce]
• DIDEMNILACTONE-A AND DIDEMNILACTONE-B AND NEODIDEMNILACTONE, 3 NEW FATTY-ACID METABOLITES ISOLATED FROM THE TUNICATE DIDEMNUM MOSELEYI (HERDMAN)（1994-06） [Web of Scientce]
• Structures of monodontamides A, B, C, D, E, and F, six new alkaloids isolated from the marine gastropod mollusc Monodonta labio (Linné)（1994） [DOI]
• Monodontamides A, B, and C, three new putrescine alkaloids from the marine gastropod mollusc Monodonta labio (Linné)（1993-11-12） [DOI]
• TOTAL SYNTHESIS OF NATURAL (-)-PTAQUILOSIN, THE AGLYCON OF A POTENT BRACKEN CARCINOGEN PTAQUILOSIDE, AND THE (+)-ENANTIOMER AND THEIR DNA CLEAVING ACTIVITIES（1993-04） [Web of Scientce]
• AN EFFICIENT ENANTIOSELECTIVE SYNTHESIS OF INDICINE N-OXIDE, AN ANTITUMOR PYRROLIZIDINE ALKALOID（1993-02） [Web of Scientce]
• TOTAL SYNTHESIS OF OPTICALLY-ACTIVE MONOCROTALINE, A CARCINOGENIC PYRROLIZIDINE ALKALOID POSSESSING AN 11-MEMBERED RETRONECINE DILACTONE（1992-11） [Web of Scientce]
• TOTAL SYNTHESIS OF OPTICALLY-ACTIVE INTEGERRIMINE, A 12-MEMBERED DILACTONIC PYRROLIZIDINE ALKALOID OF RETRONECINE TYPE（1992-01） [Web of Scientce]
• NOVEL TRANSFORMATION OF FORMYL GROUPS INTO HYDROXYL-GROUPS UTILIZING DEFORMYLATIVE AUTOXIDATION OF ALDEHYDES（1991-12） [Web of Scientce]
• Further Chemical Studies on Anisatin, a Neurotoxic Sesquiterpenoid Having a β-Lactone.（1991-09） [Web of Scientce]
• DIDEMNILACTONE AND NEODIDEMNILACTONE, 2 NEW FATTY-ACID METABOLITES POSSESSING A 10-MEMBERED LACTONE FROM THE TUNICATE DIDEMNUM-MOSELEYI (HERDMAN)（1991-09） [Web of Scientce]
• FACTORS THAT CAUSE CONTRASTERIC ALKYLATION OF A CYCLOPENTANE-1,2-DICARBOXYLIC ACID MONOESTER（1991-08） [Web of Scientce]
• THE 3-DIMENSIONAL STRUCTURE OF NEOHALICHOLACTONE, AN UNUSUAL FATTY-ACID METABOLITE FROM THE MARINE SPONGE HALICHONDRIA-OKADAI KADOTA（1991-05） [Web of Scientce]
• Synthesis of(-)-Neoanisatin, a Neurotoxic Sesquiterpenoid Having a Novel Spiro β-Lactone.（1991-04） [Web of Scientce]
• Synthesis of(-)-Noranisatin, an Oxidation Product of a Neurotoxic Sesquiterpenoid Anisatin Having a Novel Spiro β-Lactone.（1991-03） [Web of Scientce]
• Total Synthesis of(±)-(Z)-9-(Bromomethylene)-1,5,5-trimethylspiro[5.5]undeca-1,7-dien-3-one, a Brominated Sesquiterpene of the Chamigrane Type.（1991-03） [Web of Scientce]
• ALKYLATION OF NUCLEOSIDES BY DEHYDROMONOCROTALINE, THE PUTATIVE TOXIC METABOLITE OF THE CARCINOGENIC PYRROLIZIDINE ALKALOID MONOCROTALINE（1991-02） [Web of Scientce]
• ON THE MECHANISM OF THE CLEAVAGE REACTION OF (METHYLTHIO)METHYL ETHER WITH TRIPHENYLMETHYL CATION（1991-02） [Web of Scientce]
• STEREOSELECTIVE SYNTHESIS OF (-)-TRACHELANTHIC ACID AND (+)-VIRIDIFLORIC ACID, NECIC ACID COMPONENTS OF PYRROLIZIDINE ALKALOIDS FROM A COMMON INTERMEDIATE（1990-12） [Web of Scientce]
• Stereocontrolled Total Synthesis of(-)-Anisatin : A Neurotoxic Sesquiterpenoid Possessing a Novel Spiro β-Lactone.（1990-11） [Web of Scientce]
• A Biogenetic-Type Synthesis of(±)-Aplysiadiol, a Brominated Diterpene Isolated from the Marine Mollusc Aplysia kurodai.（1990） [Web of Scientce]
• ACUTE MICROCIRCULATORY CHANGES INDUCED BY INTRAVENOUS ADMINISTRATION TO RABBITS OF PTAQUILOSIDE, A BRACKEN CARCINOGEN（1989-11） [Web of Scientce]
• SYNTHESIS OF A FUNCTIONALIZED CARBOCYCLIC SKELETON OF PTAQUILOSIN, THE AGLYCONE OF A BRACKEN CARCINOGEN PTAQUILOSIDE BASED ON AN INTRAMOLECULAR DIELS-ALDER REACTION（1989-05） [Web of Scientce]
• TOTAL SYNTHESIS OF PTAQUILOSIN - THE AGLYCON OF PTAQUILOSIDE, A POTENT BRACKEN CARCINOGEN（1989-03） [Web of Scientce]
• Stereocontrolled Total Synthesis of(±)-Ptaquilosin, the Aglycone of Ptaquiloside, a Bracken Carcinogen.（1989） [Web of Scientce]
• PTAQUILOSIN, THE AGLYCONE OF A BRACKEN CARCINOGEN PTAQUILOSIDE - CHEMICAL DERIVATION FROM PTAQUILOSIDE AND THE REACTIVITY（1989） [Web of Scientce]
• HALICHOLACTONE AND NEOHALICHOLACTONE, 2 NOVEL FATTY-ACID METABOLITES FROM THE MARINE SPONGE HALICHONDRIA-OKADAI KADOTA（1989） [Web of Scientce]
• AN EFFICIENT ENANTIOSELECTIVE SYNTHESIS OF (+)-INDICINE N-OXIDE, AN ANTITUMOR PYRROLIZIDINE ALKALOID（1989） [Web of Scientce]
• A TIN-MEDIATED ONE-STEP SYNTHESIS OF (+)-DICROTALINE, AN 11-MEMBERED DILACTONIC PYRROLIZIDINE ALKALOID（1988-08） [Web of Scientce]
• A BROMINATED QUINAZOLINEDIONE FROM THE MARINE TUNICATE PYURA-SACCIFORMIS（1988-03） [Web of Scientce]
• TOTAL SYNTHESIS OF OPTICALLY-ACTIVE MONOCROTALINE, A CARCINOGENIC PYRROLIZIDINE ALKALOID HAVING AN 11-MEMBERED DILACTONE（1988） [Web of Scientce]
• AN EFFICIENT ENANTIOSELECTIVE SYNTHESIS OF THE (-)-N-(ETHOXYCARBONYL)METHYL GEISSMAN-WAISS LACTONE - A PRACTICAL SYNTHETIC ROUTE TO (+)-RETRONECINE（1987-06） [Web of Scientce]
• ISOLATION OF THE STRAINED BRIDGEHEAD ENOL ETHER OF A BICYCLO[3.3.1]NONAN-2-ONE SYSTEM（1987） [Web of Scientce]
• Stereocontrolled Total Synthesis of(±)-Norpatchoulenol and Two Metabolites of Patchouli Alcohol, (±)-Hydroxy Patchouli Alcohol and the Corresponding(±)-Carboxylic Acid.（1987） [Web of Scientce]
• PTAQUILOSIDE, A POTENT CARCINOGEN ISOLATED FROM BRACKEN FERN PTERIDIUM-AQUILINUM VAR LATIUSCULUM - STRUCTURE ELUCIDATION BASED ON CHEMICAL AND SPECTRAL EVIDENCE, AND REACTIONS WITH AMINO-ACIDS, NUCLEOSIDES, AND NUCLEOTIDES（1987） [Web of Scientce]
• STRUCTURES OF NEW P-HYDROXYSTYRENE GLYCOSIDES, PTELATOSIDE-A AND PTELATOSIDE-B ISOLATED FROM BRACKEN FERN, PTERIDIUM-AQUILINUM VAR LATIUSCULUM, AND SYNTHESIS OF PTELATOSIDE-A（1987） [Web of Scientce]
• STEREOCONTROLLED SYNTHESIS OF POLYFUNCTIONALIZED TRANS-HYDRINDAN SYSTEMS - A MODEL STUDY TOWARD ANISATIN（1986-04） [Web of Scientce]
• 4 NEW C-15 ACETYLENIC POLYENES OF BIOGENETIC SIGNIFICANCE FROM THE RED ALGA LAURENCIA-OKAMURAI - STRUCTURES AND SYNTHESIS（1986） [Web of Scientce]
• ISOLATION OF (10R,11R)-(+)-SQUALENE-10,11-EPOXIDE FROM THE RED ALGA LAURENCIA-OKAMURAI AND ITS ENANTIOSELECTIVE SYNTHESIS（1986） [Web of Scientce]
• TOTAL SYNTHESIS OF OPTICALLY-ACTIVE INTEGERRIME, A 12-MEMBERED DILACTONIC PYRROLIZIDINE ALKALOID OF RETRONECINE TYPE .1. ENANTIOSELECTIVE SYNTHESIS OF THE PROTECTED (+/-)-INTEGERRINECIC ACID（1986） [Web of Scientce]
• TOTAL SYNTHESIS OF OPTICALLY-ACTIVE INTEGERRIMINE, A 12-MEMBERED DILACTONIC PYRROLIZIDINE ALKALOID OF RETRONECINE TYPE .2. ENANTIOSELECTIVE SYNTHESIS OF (+)-RETRONECINE（1986） [Web of Scientce]
• TOTAL SYNTHESIS OF OPTICALLY-ACTIVE INTEGERRIMINE, A 12-MEMBERED DILACTONIC PYRROLIZIDINE ALKALOID OF RETRONECINE TYPE .3. REGIOSELECTIVE ELABORATION OF THE UNSYMMETRICAL 12-MEMBERED DILACTONE AND TOTAL SYNTHESIS OF (-)-INTEGERRIMINE（1986） [Web of Scientce]
• STEREOCONTROLLED TOTAL SYNTHESIS OF (+)-TUTIN AND (+)-ASTEROMURIN-A, TOXIC PICROTOXANE SESQUITERPENES（1986） [Web of Scientce]
• ISOLATION OF PETASITENINE, A CARCINOGENIC PYRROLIZIDINE ALKALOID FROM FARFUGIUM-JAPONICUM（1985-11） [Web of Scientce]
• GENOTOXICITY OF PTAQUILOSIDE, A BRACKEN CARCINOGEN, IN THE HEPATOCYTE PRIMARY CULTURE DNA-REPAIR TEST（1985） [Web of Scientce]
• A NEW METHOD FOR DIRECT OXIDATION OF THE METHYLENE GROUP ADJACENT TO A CYCLOPROPANE RING TO THE KETO GROUP（1985） [Web of Scientce]
• Total Synthesis of(±)-(Z)-9-(Bromomethylene)-1,5,5-trimethylspiro[5.5]undeca-1,7-dien-3-one, a Brominated Sesquiterpene of Chamigrane Type.（1985） [Web of Scientce]
• STUDIES ON PTERIDIUM-AQUILINUM VAR LATIUSCULUM .4. ISOLATION OF 3 PARA-HYDROXYSTYRENE GLYCOSIDES AND AN EFFICIENT METHOD FOR THE ISOLATION OF PTAQUILOSIDE, AN UNSTABLE BRACKEN CARCINOGEN（1985） [Web of Scientce]
• ACTIONS OF PICROTOXININ AND RELATED-COMPOUNDS ON THE FROG SPINAL-CORD - THE ROLE OF A HYDROXYL-GROUP AT THE 6-POSITION IN ANTAGONIZING THE ACTIONS OF AMINO-ACIDS AND PRESYNAPTIC INHIBITION（1984） [Web of Scientce]
• SEPARATION OF CARCINOGENIC FRACTION OF BRACKEN FERN（1984） [Web of Scientce]
• ISOLATION AND STRUCTURES OF 2 NEW PARA-HYDROXYSTYRENE GLYCOSIDES, PTELATOSIDE-A AND PTELATOSIDE-B FROM BRACKEN, PTERIDIUM-AQUILINUM VAR LATIUSCULUM, AND SYNTHESIS OF PTELATOSIDE-A（1984） [Web of Scientce]
• HYPERPLASTIC NODULES OF THE LIVER INDUCED IN RATS FED BRACKEN DIET（1984） [Web of Scientce]
• Stereocontrolled Total Synthesis of(±)-Hydroxy Patchouli Alcohol and the Corresponding(±)-Carboxylic Acid, Metabolites of Patchouli Akcohol, and(±)-Norpatchoulenol.（1984） [Web of Scientce]
• STEREOCONTROLLED TOTAL SYNTHESIS OF (-)-PICROTOXININ AND (+)-CORIAMYRTIN VIA A COMMON ISOTWISTANE INTERMEDIATE（1984） [Web of Scientce]
• STEREOCONTROLLED TOTAL SYNTHESIS OF (+)-TUTIN, A TOXIC SESQUITERPENE OF PICROTOXANE TYPE（1984） [Web of Scientce]
• STEREOCONTROLLED TOTAL SYNTHESIS OF (+)-ASTEROMURIN-A, A PICROTOXANE SESQUITERPENE ISOLATED FROM THE SCALE INSECT ASTEROCOCCUS-MURATAE KUWANA（1984） [Web of Scientce]
• REPRODUCTION OF ACUTE BRACKEN POISONING IN A CALF WITH PTAQUILOSIDE, A BRACKEN CONSTITUENT（1984） [Web of Scientce]
• STRUCTURE AND SYNTHESIS OF MIYAGININ, A PARA-ALLYLPHENYL GLYCOSIDE FROM LESPEDEZA-THUNBERGII FORMA MACRANTHA（1984） [Web of Scientce]
• CARCINOGENICITY IN RATS OF PTAQUILOSIDE ISOLATED FROM BRACKEN（1984） [Web of Scientce]
• STRUCTURE OF PTAQUILOSIDE TETRAACETATE, C28H38O12（1984） [Web of Scientce]
• A Convenient Synthesis of(±)-Retronecine.（1983） [Web of Scientce]
• Total Synthesis of(±)-Cycloseychellene, a Novel Tetracyclic Sesquiterpene.（1983） [Web of Scientce]
• SEPARATION AND DETERMINATION OF MACROCYCLIC PYRROLIZIDINE ALKALOIDS OF THE OTONECINE TYPE PRESENT IN THE EDIBLE PLANT PETASITES-JAPONICUS BY REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY（1983） [Web of Scientce]
• FARFUGINE, A NEW PYRROLIZIDINE ALKALOID ISOLATED FROM FARFUGIUM-JAPONICUM KITAM（1983） [Web of Scientce]
• PTAQUILOSIDE, A NOVEL NORSESQUITERPENE GLUCOSIDE FROM BRACKEN, PTERIDIUM-AQUILINUM VAR LATIUSCULUM（1983） [Web of Scientce]
• STEREOCHEMISTRY OF PTAQUILOSIDE, A NOVEL NORSESQUITERPENE GLUCOSIDE FROM BRACKEN, PTERIDIUM-AQUILINUM VAR LATIUSCULUM（1983） [Web of Scientce]
• Total Synthesis of (±) -Otonecine, a Necine Base of Pyrrolizidine Alkaloids.（1983） [Web of Scientce]
• Synthesis of(±)-Carba-Analogs of 5-HPETE and Leukotriene A4, Unstable Intermediates of Slow-Reacting Substance(SRS).（1982） [Web of Scientce]
• STRUCTURAL ANALOGS OF LEUKOTRIENE-C AND LEUKOTRIENE-D AND THEIR CONTRACTILE ACTIVITIES（1982） [Web of Scientce]
• ISOLATION AND STRUCTURES OF TRANS-LAURENCENYNE, A POSSIBLE PRECURSOR OF THE C-15 HALOGENATED CYCLIC ETHERS, AND TRANS-NEOLAURENCENYNE FROM LAURENCIA-OKAMURAI（1982） [Web of Scientce]
• Total Synthesis of an Antitumour Antibiotic, (±)-Reductiomycin.（1982） [Web of Scientce]
• STRUCTURE AND SYNTHESIS OF REDUCTILINE, A NOVEL METABOLITE FROM A VARIANT OF STREPTOMYCES-ORIENTALIS（1982） [Web of Scientce]
• (10R, 11R)-(+)-SQUALENE-10, 11-EPOXIDE - ISOLATION FROM LAURENCIA-OKAMURAI AND THE ASYMMETRIC-SYNTHESIS（1982） [Web of Scientce]
• A CONVENIENT PREPARATION OF N-ACYLPYROGLUTAMIC ACID（1981） [Web of Scientce]
• A NEW METHOD FOR CLEAVAGE OF ALIPHATIC METHYL ETHERS（1981） [Web of Scientce]
• LAURENCENYNE, A PLAUSIBLE PRECURSOR OF VARIOUS NON-TERPENOID C-15-COMPOUNDS, AND NEOLAURENCENYNE FROM THE RED ALGA LAURENCIA-OKAMURAI（1981） [Web of Scientce]
• Recent Studies on the Chemical Synthesis of Eicosanoids.（1980）
• Synthesis of 15,17-Methylene-prostaglandins.（1979）
• Synthesis of a New Prostaglandin Endoperoxide (PG H2) Analog and Its Function as an Inhibitor of the Biosynthesis of Thromboxane A2 (TX A2).（1979）
• Selective Epoxidation of Eicosa-cis-5,8,11,14-tetraenoic(Arachidonic)Acid and Eicosa-cis-8,11,14-trienoic Acid.（1979）
• Total Synthesis of (S)-12 Hydroxy-5,8,14-cis-10-trans-eicosatetraenoic Acid(Samuelsson's HETE).（1978）
• Synthesis of 15,19-Methano-ω-nor-prostaglandins.（1977）
• The Alkaloids from the Fruits of the Plant Daphniphyllaceae.（1974）
• Chemical Studies on Nitrogen Heterocylic Skeleton of the Daphniphyllum Alkaloids.（1974）
• The Structure of Daphniphyllidine.（1973）
• Biosynthesis of Daphniphyllum Alkaloids.（1973）
• Biosynthesis of Daphnilactone-B.（1973）
• 2-Azabicyclo[3.3.1]non-1-ene Systems as Reaction Intermediates.（1972）
• Daphnilactone-B, a Major Alkaloid, from the Fruits of Daphniphyllaceae.（1972）

その他業績

• 生物発光の原理と応用（2012-07）
• 生物発光の原理と応用（2012-04）
• オワンクラゲの生物発光機構（2009-04）
• 生物はなぜ光るのか－生物発光とその応用－（2005-10）
• 発光巻貝ラチアの発光機構研究:ラチアルシフェリンアナログのK_mと発光反応生成物の分析（2005-03-11） [J-GLOBAL]
• 生物発光のメカニズムとその応用（2002）
• 有機合成における電極反応の応用（共著）（1998-09） [Web of Scientce]
• 絵で見るバイオ;オワンクラゲの増感生物発光機構（1998）
• トピックス:オワンクラゲの増感生物発光機構（1998）
• 発光反応(特集・光る生物-ホタルを中心に).（1996） [CiNii Research (CiNii Articles)] [CiNii Books] [Othres link]
• 植物神経毒アニサチンの合成（1991）
• 植物起源の発がん物質の合成（1990）
• 多官能性天然生理活性物質の全合成.大環状ピロリチジンアルカロイドの全合成（1988-07） [Web of Scientce]
• ピクロトキサン型セスキテルペノイドの全合成（1986）

講演・口頭発表等

• 生物発光、温故知新（2013-11）
• ホタル生物発光系をモデルとした人工発光系の創製と実用化（2012-06）
• 生物発光の化学とその イメージングへの応用（2007-10）
• 生物発光研究の新展開：ラチア、ホタル、発光ゴカイ（2006-06）
• ホタルの光～生物の光通信～（2005-08）
• 生物はなぜ光るのか－生物発光とその応用－（2005-01）
• Targetted Pursuit of Challenging Bioactive Molecules [Summary Report of Research Projekt (1999~2002)]（2004-04）
• 巻き貝ラチア生物発光の分子機構（2001-09）
• 生物と光―生物発光の分子基盤研究とその応用（2000-11）
• 発光クラゲの緑色蛍光蛋白質（ＧＦＰ）の化学（1997-05）

書籍等出版物

• 医学のための細胞生物学：コラム「ＧＦＰと下村脩先生」（2009-08）
• 岩波：科学 Vol. 71, No. 4 (2009).特集「クラゲ」-オワンクラゲの生物発光機構-（2009-04）
• 天然物化学ー 海洋生物編： 1.2.7「海洋生物の発光現象」（2008-06）
• 生物物理学ハンドブック： 7.6 生物発光（2007-04）
• 別冊『化学：分子イメージング最前線』 1.4 入門「自然界に光る生き物とその原理」（2007-04）
• 天然物化学ー植物編（2007-02）
• バイオサイエンス化学－生命から学ぶ化学－ 第４章 生命の物質－炭素化合物（2003-03）
• 有機化学実験のてびき-3（1990）
• 有機化学実験のてびき-4（1990）
• 有機化学実験のてびき-1（1988）

作品等

共同研究・競争的資金等の研究課題

メディア報道

産業財産権

• 検出装置、検出方法、及び検出器（特開2021-16798）
• 特願2014-189314 新規複素環式化合物及びその塩、並びに、発光基質組成物(原特願2013-198998; 2013/9/25)（特許第6353751）
• 特願2013-530040：ルシフェラーゼの発光基質（特許第6049019）
• 特願2013-097755 新規ハロゲン化水素塩（特許第6011974号）
• PCT/JP2012/071207 (特願2011-182224) Int. Appl.Luciferin analog and its use for luminescent substrate for luciferase and luminescence detection kit（ZL201280041269.3）
• 特願2010-137031 遷移元素触媒およびその製造方法、並びに選択的水素添加方法（特許第5605619）
• PCT/JP2012/071207 (特願2011-182224) Int. Appl.Luciferin analog and its use for luminescent substrate for luciferase and luminescence detection kit（US2014-0221665A1）
• PCT/JP2012/071207 (特願2011-182224) Int. Appl.Luciferin analog and its use for luminescent substrate for luciferase and luminescence detection kit（EP2754657A1）
• 特願2012-265382 環化化合物の製造方法、及び、環化化合物を含有する溶液の発光方法（特開2014-108957）
• 特願2009-064595：波長が制御されたルシフェラーゼの発光基質および製造方法（特許第5550035号）
• 特願2008-023396:「ルシフェラーゼの発光基質」（特許第5464311）
• 特願2012-049619：ルシフェラーゼの発光基質（特開2013-184909）
• PCT/JP2012/071207 (特願2011-182224) Int. Appl.Luciferin analog and its use for luminescent substrate for luciferase and luminescence detection kit（WO/2013/027770 A1）
• PCT/JP2007/056227（特願2008-509744）:複素環化合物及び発光方法（特許第5194258号）
• 特願2011-108654 蛍光色素（特開2012-241014）
• （取下げ擬制）特願2011-182224：ルシフェラーゼの発光基質（(取下げ擬制)特願2011-182224）
• 特願2009-187979：抗体－ルシフェリルペプチド複合体、これを用いた被検物質の測定方法及び被検物質の測定試薬並びに測定試薬の調製方法（特開2011-037791）
• 特願2004-379971：天然型L-システインまたはその誘導体を用いたホタル発光基質の生合成システム及び本システムを含んだ発光基質溶液（特許4682310）
• PCT/JP2009/000376：ルシフェラーゼの発光基質（US2011/033878A1）
• PCT/JP2010/053177波長が制御されたルシフェラーゼの発光基質および製造方法（WO/2010/106896 A1）
• 特願2009-027654 ルシフェラーゼの発光基質（特開2010-180191）
• 特願2004-067098: イミダゾピラジノン誘導体及びビスアミノピラジノン誘導体並びに化学発光物質（特許4561132）
• 特願2008-244890［アシルアミノピラジナート-O,N］ーボロン誘導体および蛍光色素（特開2010-077040）
• 特願2008-192596: ε-N-ルシフェリルリシン化合物、これを用いたペプチド標識剤及びペプチド標識方法（特開2010-30918）
• 特願2003-195905: ビスイミダゾピラジノン系新規蛍光性・化学発光生物質（特許4363098）
• 特願2003-026134: 還元触媒及びその製造方法、並びに選択的水素添加方法（特許4116891）
• 特願2006-086175:複素環化合物及び発光方法（特開2007-194258）
• 特願2002-33258: パラジウム触媒を用いた選択的水素添加反応方法（特許第3976579）
• 特願2005-031574:複素環化合物及び発光甲虫ルシフェラーゼ発光系用発光物質（特開2006-219381）
• PCT/JP2005/23847：天然型L-システインまたはその誘導体を用いたホタル発光基質の生合成システム及び本システムを含んだ発光基質溶液（WO/2006/070775）
• 特願2003-292606: 発光キノコヤコウタケの簡便栽培法（特開2005-27634）
• 特願2003-116616: 芳香族有機化合物の分解方法（特開2004-321275）
• 特願2002-80931: 新規なパラジウム触媒（特開2003-275593）
• 特願2002-80930: パラジウムブラックの新規な製造方法（特開2003-275586）
• 特願2002-80929: 担持型パラジウム触媒（特開2003-275585）
• 特願2000-340644: アルケン類の選択的水素添加反応並びにこれに用いる触媒及び触媒構造体（特開2002-145818）
• 特願2000-133584: アルケン類の選択的水素添加方法（特開2001-316315）
• 特願平11-137401: アルケンの選択的水素添加方法（特開2000-328278）
• 特開昭52-91847: プロスタグランジン関連化合物（特開昭52-91847）
• 特開昭52-77027: 2－(4－イソブチルフェニル)プロピオン酸（特開昭52-77027）
• 特開昭52-62237: α置換フェニル・アルカン・カルボン酸の製造法（特開昭52-62237）
• 特開昭52-53833: α置換フェニル・アルカン・カルボン酸の製造法（特開昭52-53833）
• 特開昭51-86447: 1β，5β－2－オキサ－3－ヒドロキシ－6β－置換メチル－7α－置換オキシ－ビシクロ［3.3.0］オクタン類の製造法（特開昭51-86447）

所属学協会

• 日本化学会
• 生物発光・化学発光研究会

委員歴

担当経験のある科目

• 有機化学2
• 有機化学2
• 有機化学2

社会貢献活動

学術貢献活動