学位

• 理学博士(東北大学 1991.3)

経歴

学歴

受賞

その他

論文

• Dual-Mode Emission and Solvent-Desorption Dependent Kinetic Properties of Crystalline-State Chemiluminescence Reaction of 9-Phenyl-10-(2-phenylethynyl)anthracene Endoperoxide [DOI]
• Synthesis and anti-tumor activities in human leukemia-derived cells of polyenylpyrroles with a methyl group at the conjugated polyene terminus [DOI]
• An Inhibition Effect on an Intracrystalline Reaction by a Crystal Lattice: Analyses of the Chemiluminescence Reaction of 9,10-Diphenylanthracene Endoperoxide Initiated by Heating of a Crystal Sample [DOI] [Othres link]
• S-Series Coelenterazine-Driven Combinatorial Bioluminescence Imaging Systems for Mammalian Cells [DOI]
• C-Series Coelenterazine-Driven Bioluminescence Signature Imaging [DOI]
• Quantum yield of near-infrared bioluminescence with firefly luciferin analog: AkaLumine [DOI]
• Analyses of chemiluminescence reactions of fluorophore-linked 1,2-dioxetane isomers in crystals heating at elevated temperature including a development of a simultaneous measurement method of thermal diffusivity and light emission for a single crystal [DOI]
• A stable chemiluminophore, adamantylideneadamantane 1,2-dioxetane: from fundamental properties to utilities in mechanochemistry and soft crystal science [DOI]
• Crystalline-state chemiluminescence reactions of two-fluorophore-linked adamantylideneadamantane 1,2-dioxetane isomers accompanied by solid-to-solid phase transitions [DOI]
• Intracrystalline Kinetics Analyzed by Real-Time Monitoring of a 1,2-Dioxetane Chemiluminescence Reaction in a Single Crystal [DOI]
• Singlet-oxygen Chemiluminescence from Heated Crystal Samples of 9,10-Diphenylanthracene Endoperoxides [DOI]
• Development of phenyl oligoene-type firefly luciferin analogues with extended π-electronic conjugation for near-infrared bioluminescence [DOI]
• Synthesis of polyenylpyrrole derivatives with selective growth inhibitory activity against T-cell acute lymphoblastic leukemia cells [DOI]
• Color-tunable bioluminescence imaging portfolio for cell imaging [DOI] [Othres link] [Othres link]
• A Very Bright Far-Red Bioluminescence Emitting Combination Based on Engineered Railroad Worm Luciferase and 6′-Amino-Analogs for Bioimaging Purposes [DOI] [Othres link]
• Bright near-infrared chemiluminescent dyes: Phthalhydrazides conjugated with fluorescent BODIPYs [DOI] [Web of Scientce]
• Development of near‐infrared firefly luciferin analogue reacted with wild‐type and mutant luciferases [DOI] [Othres link] [Othres link] [Othres link]
• Isomeric difference in the crystalline-state chemiluminescence property of an adamantylideneadamantane 1,2-dioxetane with a phthalimide chromophore [DOI] [Othres link]
• Phrixotrix luciferase and 6’-aminoluciferins reveal a larger luciferin phenolate binding site and provide novel far-red combinations for bioimaging purposes [DOI]
• Halogen-substituent effect on the spectroscopic properties of 2-phenyl-6-dimethylaminobenzothiazoles [DOI] [Scopus] [Scopus]
• Spectroscopic properties of push-pull 2-(4-carboxyphenyl)-6-dimethylaminobenzothiazole derivatives in solution and the solid state [DOI] [Scopus] [Scopus]
• Synthesis and Luminescence Properties of Near-Infrared N-Heterocyclic Luciferin Analogues for In Vivo Optical Imaging [DOI] [Othres link]
• The proton and metal binding sites responsible for the pH-dependent green-red bioluminescence color tuning in firefly luciferases [DOI] [Othres link] [Othres link]
• Structure-fluorescence relationship of push-pull 2-phenylbenzothiazole derivatives designed based on the firefly light-emitter [DOI] [Scopus] [Scopus]
• Toward bioluminescence in the near-infrared region: Tuning the emission wavelength of firefly luciferin analogues by allyl substitution [DOI]
• Quantum yield improvement of red-light-emitting firefly luciferin analogues for in vivo bioluminescence imaging [DOI]
• Electronic and Steric Effects of Cyclic Amino Substituents of Luciferin Analogues on a Firefly Luciferin-Luciferase Reaction [DOI] [Web of Scientce]
• Spectroscopic Properties of Amine-substituted Analogues of Firefly Luciferin and Oxyluciferin [DOI] [Othres link]
• Spectroscopic properties of BF2 complexes of N-(5-phenyl-2-pyrazinyl) pivalamides exhibiting fluorescence in solution and solid state [DOI] [Web of Scientce]
• Glu311 and Arg337 Stabilize a Closed Active-site Conformation and Provide a Critical Catalytic Base and Countercation for Green Bioluminescence in Beetle Luciferases [DOI] [Web of Scientce] [Othres link]
• Enhanced brightness of 2,6-diphenylthiazolo[4,5-b]pyrazines by introducing double electron donating groups [DOI] [Web of Scientce]
• Molecular Origin of Color Variation in Firefly (Beetle) Bioluminescence: A Chemical Basis for Biological Imaging [DOI] [Web of Scientce]
• Fluorescence Properties of Diphenylthiazolo[4,5-b]pyrazines Tuned by Donor-Acceptor Substituent Effects [DOI] [PubMed] [Web of Scientce]
• Substituent effects on fluorescence properties of thiazolo[4,5-b]pyrazine derivatives [DOI] [Web of Scientce]
• Synthesis and chemiluminescent properties of 6,8-diaryl-2-methylimidazo[1,2-alpha]pyrazin-3(7H)-ones: Systematic investigation of substituent effect at para-position of phenyl group at 8-position [DOI] [Web of Scientce]
• Bioluminescence of Beetle Luciferases with 6 '-Amino-D-luciferin Analogues Reveals Excited Keto-oxyluciferin as the Emitter and Phenolate/Luciferin Binding Site Interactions Modulate Bioluminescence Colors [DOI] [Web of Scientce]
• Chemiluminescent 2,6-diphenylimidazo[1,2-a]pyrazin-3(7H)-ones: a new entry to Cypridina luciferin analogues [DOI] [Web of Scientce]
• Synthesis and luminescence properties of biphenyl-type firefly luciferin analogs with a new, near-infrared light-emitting bioluminophore [DOI] [Web of Scientce]
• Development of simple firefly luciferin analogs emitting blue, green, red, and near-infrared biological window light [DOI]
• Evaluation of Bioluminescence Activity of Firefly Luciferin Nucleotide Derivatives
• 5-[4-(Dimethylamino)phenyl]-2-benzamidopyrazines: fluorescent dyes based on Cypridina oxyluciferin [DOI] [Web of Scientce]
• Spectroscopic studies of the color modulation mechanism of firefly (beetle) bioluminescence with amino-analogs of luciferin and oxyluciferin [DOI] [PubMed]
• Studies on (-)ESI-MS/MS of a glycosaminoglycan disaccharide N-acetyllactosamine-6,6 '-disulfate disodium salt-Charge-localization isomers [DOI] [Web of Scientce]
• Bioluminescence characteristics of the fruiting body of Mycena chlorophos [DOI] [PubMed] [Web of Scientce]
• Influence of electron-donating and electron-withdrawing substituents on the Chemiluminescence behavior of Coelenterazine analogs [DOI] [Web of Scientce]
• Colorimetric and fluorometric sensing of the Lewis acidity of a metal ion by metal-ion complexation of imidazo[1,2-a]pyrazin-3(7H)-ones [DOI] [Web of Scientce]
• Color modulation mechanism of firefly (beetle) bioluminescence based on photochemistry [Web of Scientce]
• Synthesis and properties of bis(pyrazino[2 ',3 ':4,5]imidazole)-fused 1,2,5,6-tetrahydro-1,4,5,8,9,10-hexaazaanthracenes: a new fluorescent nitrogen-rich heterocycle [DOI] [Web of Scientce]
• Synthesis and fluorescence properties of difluoro[amidopyrazinato-O,N]boron derivatives: a new boron-containing fluorophore [DOI] [Web of Scientce]
• Distinction of Sialyl Anomers on ESI- and FAB-MS/MS: Stereo-Specific Fragmentations [DOI] [Web of Scientce]
• Spectroscopic Studies of the Light-Color Modulation Mechanism of Firefly (Beetle) Bioluminescence [DOI] [Web of Scientce]
• The reaction mechanism for the high quantum yield of Cypridina (Vargula) bioluminescence supported by the chemiluminescence of 6-aryl-2-methylimidazo[1,2-a]pyrazin-3(7H)-ones (Cypridina luciferin analogues) [DOI] [Web of Scientce]
• Spectroscopic and density functional theory studies of the molecular geometry and electronic structure of classical and nonclassical radical ions derived from 7-benzhydrylidenenorbornene analogues [DOI] [Web of Scientce]
• Chemiluminescence of 6-aryl-2-methylimidazo[1,2-a]pyrazin-3(7H)-ones in DMSO/TMG and in diglyme/acetate buffer: support for the chemiexcitation process to generate the singlet-excited state of neutral oxyluciferin in a high quantum yield in the Cypridina (Vargula) bioluminescence mechanism [DOI] [Web of Scientce]
• Real light emitter in the bioluminescence of the calcium-activated photoproteins aequorin and obelin: light emission from the singlet-excited state of coelenteramide phenolate anion in a contact ion pair [DOI] [Web of Scientce]
• Bio-inspired materials for electron donors and charge-transfer complex formation based on the imidazopyrazinone luciferin core [DOI] [Web of Scientce]
• Construction of a new firefly bioluminescence system using L-luciferin as substrate [DOI] [Web of Scientce]
• Substituent effects on the kinetics for the chemiluminescence reaction of 6-arylimidazo[1,2-a]pyrazin-3(7H)-ones (Cypridina luciferin analogues): support for the single electron transfer (SET)-oxygenation mechanism with triplet molecular oxygen [DOI] [Web of Scientce]
• Substituent effects on the spectroscopic properties of solvatochromic 2-phenylimidazo[1,2-a]pyrazin-3(7H)-ones: an effective control for the colorimetric sensor properties [DOI] [Web of Scientce]
• Spectroscopic and DFT studies of nonclassical and classical radical cations of 7-benzhydrylidenenorbornene analogues: contrasting molecular geometry and electronic structures originating from the different patterns of electronic coupling [DOI] [Web of Scientce]
• Firefly luciferase exhibits bimodal action depending on the luciferin chirality [DOI] [Web of Scientce]
• Spectroscopic and DFT evidence for a nonclassical radical cation derived from 7-benzhydrylidenenorbornene [DOI] [Web of Scientce]
• Bioluminescence activity of Latia luciferin analogues: replacement of the 2,6,6-trimethylcyclohexene ring onto the methyl-substituted phenyl groups [DOI] [Web of Scientce]
• Characterization of [1-13C]- Specifically Labeled Amino Acids Using ESIMS/MS in the Selected Reaction Monitoring Mode [DOI] [CiNii Research (CiNii Articles)] [CiNii Books]
• Regioselective phenyl-substitution effects on the solvatochromism of 2-phenylimidazo[1,2-a]pyrazin-3(7H)-one derivatives: expansion of the color variation range of a visible indicator for the proton donor ability of solvents [DOI] [Web of Scientce]
• Substituent effects on the solvatochromism of 2-phenylimidazopyrazinones: Effective control of the color variation range and sensitivity toward an indication of the proton-donor ability of solvents by an electron-withdrawing group substitution [DOI] [Web of Scientce]
• Synthesis and chemiluminescence of novel p-conjugated bisimidazopyrazinone derivatives
• Spectral control of 2-arylimidazopyrazinone derivatives: substituent and an interaction with biological molecules
• The chemiluminescence reaction mechanism of imidazopyrazinones: Effects of the reaction conditions for the chemiluminescence
• Development of the chemistry of the imidazopyrazinone- bioluminescence system: From the bio- and chemiluminescence mechanism to a design of sensor molecules
• Ionic structure of the excited light – emitter in the calcium – activated photoprotein bioluminescence”
• Synthesis and bioluminescent activity of the Latia luciferin analogs
• Synthesis of Latia luciferin benzoate analogues and their bioluminescent activity [DOI] [Web of Scientce]
• Metal-ion complexation of imidazo[1,2-a]pyrazin-3(7H)-ones: continuous changes in absorption spectra of complexes depending on the Lewis acidity of the metal ion [DOI] [Web of Scientce]
• Analysis of sugar epimers using mass spectrometry: N-acetyllactosamine-6,6 '-disulfate and the 2 '-epimer [DOI] [Web of Scientce]
• Fundamental studies on the structures and spectroscopic properties of imidazo[1,2-a]pyrazin-3(7H)-one derivatives [DOI] [Web of Scientce]
• Pd black deposited on polypropylene sheet as a highly selective catalyst for hydrogenation of alkenes [DOI] [Web of Scientce]
• Hydrogenolysis-free Hydrogenation Using Pd Black Catalyst Deposited on Pd Sheet
• Viscosity-dependent fluorescence decay of the GFP chromophore in solution due to fast internal conversion [DOI] [Web of Scientce]
• Preparation of deoxygenated derivatives of neoanisatin, a neurotoxic sesquiterpenoid having a beta-lactone [DOI] [Web of Scientce]
• Preparation and Toxic Property of Carbapicrotoxinin, a Cyclopropane-containing Analog of GABA-antagonistic Sesquiterpenoid Piricrotoxinin
• Reduction in Desorption Mass Spectrometry: Multiple Protonation on Flavins without Charge Increment [DOI] [CiNii Research (CiNii Articles)] [CiNii Books] [Othres link] [Othres link]
• Fluorescence properties of phenolate anions of coelenteramide analogues: the light-emitter structure in aequorin bioluminescence [DOI] [Web of Scientce]
• Effect of solvent and hydrogen during selective hydrogenation [DOI] [Web of Scientce]
• Hydrogenolysis-free hydrogenation by Pd black powder catalyst [DOI] [Web of Scientce]
• Improved Syntheses of Watasenia Preluciferin (Coelenterazine) and Watasenia Luciferin (Coelenterazine Disulfate), and Site Specific Syntheses of the Coelenterazine Monosulfates
• Facile Cleavage Reactions of Styrylic Olefins using Electrochemical Methods [DOI] [Othres link]
• Novel Dehydration Reaction of Neoanisatin and Transformation of Neoanisatin into Anisatin [DOI] [Web of Scientce] [Othres link]
• 93(P-2) ラチア生物発光の分子基盤(ポスター発表の部) [DOI] [CiNii Research (CiNii Articles)] [CiNii Books]
• Isoquinoline formation by a novel photochemical intermolecular cycloaddition of 1,1-diphenylethene derivatives to 1,4-dicyanobenzene [DOI] [Web of Scientce]
• Bioluminescence activity of Latia luciferin analogs [DOI] [Web of Scientce]
• Supramolecular steric effects as the means of making reactive carbon radicals persistent. Quantitative characterization of the external surface of MFI zeolites through a persistent radical probe and a langmuir adsorption isotherm [DOI] [Web of Scientce]
• Synthesis, chemi- and bioluminescence properties, and photolysis of a coelenterazine analogue having a photoreactive azido group [DOI] [Web of Scientce]
• Selective alkene hydrogenation with atomic hydrogen permeating through a Pd sheet electrode [Web of Scientce] [DOI]
• A Spectroscopic Study of Diphenylmethyl Radicals and Diphenylmethyl Carbocations Stabilized by Zeolites (共著) [DOI]
• Reversible oxygenation of a diphenylmethyl radical rendered supramolecularly persistent [DOI] [Web of Scientce]
• Reactivity and Π-Facial Selectivity of Nucleophile Addition to the Redical Cations of 7-Benzhydrylidenenorbornene Derivatives(共著) [DOI] [Web of Scientce]
• Stereoselective tandem cyclization of 1,1-diphenyl-1,n-alkadienes via photoinduced electron transfer reaction [DOI] [Web of Scientce]
• Bioluminescent properties of fluorinated semi-synthetic aequorins [DOI] [Web of Scientce]
• A novel, stereoselective photo-Ritter reaction of 1,1-diphenyl-1,6-heptadiene via photoindnced electron transfer reaction [DOI] [Web of Scientce]
• Synthesis of（±）-Isoitalicene using Electrolysis under Irradiation as a Key Step.
• Substituent effects on the chemiluminescent properties of coelenterazine analogues [DOI] [Web of Scientce]
• FAB-CID Mass Spectrometry of Imidazolone Derivatives Related to the Chromophore of Aequorea Green Fluorescent Protein(共著) [DOI] [CiNii Research (CiNii Articles)] [CiNii Books] [Othres link] [Othres link]
• Facile cleavage reactions of styrylic olefins using electrochemical methods [Web of Scientce]
• Chemi- and bioluminescence of coelenterazine analogues possessing an adamantylmethyl group [DOI] [Web of Scientce]
• Solvent and substituent effects on the fluorescent properties of coelenteramide analogues [DOI] [Web of Scientce]
• Abnormal reactivity of anisatin and neoanisatin to samarium iodide hexamethylphosphorictriamide [DOI] [Web of Scientce]
• Mechanism of the redox reaction of the Aequorea green fluorescent protein (GFP) [DOI] [Web of Scientce]
• Phytochrome Photochromism Probed by Site-Specific Mutations and Chromophore Esterification [DOI]
• Chemical nature of the light emitter of the Aequorea green fluorescent protein [DOI] [Web of Scientce]
• Shining the light: The mechanism of the bioluminescence reaction of calcium-binding photoproteins [DOI] [Web of Scientce]
• The structural origin of the color differences in the bioluminescence of firefly luciferase [DOI] [Web of Scientce]
• Mass Spectrometric Investigation of Stracture of Intermediates in Acridine Chemilumiuescance (共著) [DOI] [CiNii Research (CiNii Articles)] [CiNii Books] [Othres link] [Othres link]
• A Potential Photoaffinity Probe for Labelling the Active Site of Aequorin : A Photolabile Coelenterazine Analogue with A Triflusromethyl-diazine Group [DOI] [Web of Scientce]
• Chemi-and Bioluminescent Properties of Coelenterazine Analogues Possessing an Adamantyl Group [DOI] [Web of Scientce]
• FAB CID-MS/MS Characterization of Tetrasaccharide tri-and tetrasulbate Derived from the Antigenic Determinant Recognized by the Anti-chondroitin sulfate Monoclonal Antibody MO-225 [DOI] [Web of Scientce]
• Negative-ion fast atom bombordment tandem mass spectrometry for characterization of sulfated unsaturated disaccharides from heparin and heparan sulfate [DOI] [Web of Scientce]
• Positive-ion fast atom bombordment tandem mass spectrometry for characterization of sulfated unsaturated disaccharides from heparin and heparan sulfate [DOI] [Web of Scientce]
• Synthesis and Preliminary Chemi-and Bio-luminescence Studies of a novel Photolabile Coelenterazine Analogue with a Trifluoro methyl Diazirine Group [DOI] [Web of Scientce]
• Tandem mass spectrometry for cheracterization of unsaturated disaccharides for chondroitin sulfate, dermatan sulfate and hyaluronan [DOI] [Web of Scientce]
• Revision of the Structure of the Light-emitter in Aeguorin Bioluminescence [DOI] [Web of Scientce]
• Mass Spectrometric Studies on Chemiluminescence of Coelenterate Luciferin Analoques [DOI] [Web of Scientce]
• Secondary Ion Mass Spectrometry of Sugar Nucleotides [DOI] [Web of Scientce]
• 3-Benzyl-5-(4-hydroxyphenyl)-2-[4-(1-azi-2,2,2-tribluoroethyl) phenylacetamido] pyrazine, a Photoreactive Analogue of Coelenteramide, Synthesis and Photolysis [DOI] [Web of Scientce]
• Characterization of Positional and Anomeric Isomers of Methyl 2-0-and 3-0-Sulto-D-glucopyranosiduronic Acids and Methyl 2-0-and 3-0-Sulfo -D-glucopyranosides by Secondary Ion Mass Spectrometry [DOI]
• Mass Spectrometry of Charge-transfer Complexes of 7,7', 8,8'-Tetracyano guinodimethome-π-Donor Systems [DOI] [Web of Scientce]
• Photoinduced electron-transfer reaction of 7-benzhydrylidenenorbornene - Chemical capture of a radical cation intermediate with nonclassical cation character [DOI] [Web of Scientce]
• Detection of molecule-ions of cyclodextrin inclusion complexes [DOI] [Web of Scientce]
• Chemiluminescence of coelenterazine analogues - structures of emitting species - [DOI] [Web of Scientce]
• Chemi- and bio-luminescence of coelenterazine analogues with phenyl homologues at the C-2 position [DOI] [Web of Scientce] [Othres link]
• Inversion of the ground-state spin multiplicity by electron-withdrawing groups in trimethylenemethane derivatives generated photochemically from methylenequadricyclane derivatives [DOI] [Web of Scientce]
• Novel photoreactions of benzhydrylidenequadricyclane and quadricyclanone: a new route to trimethylenemethane and oxyallyl derivatives [DOI] [Web of Scientce]

その他業績

• ホタルの発光する仕組み
• 化学の本だな「”恐竜はホタルを見たか-発光生物が照らす進化の謎-”，大場裕一著」書評
• 化学発光と生物発光の基礎化学 [DOI] [CiNii Research (CiNii Articles)] [CiNii Books]
• ホタル生物発光の化学：基礎と応用の最前線 [CiNii Research (CiNii Articles)] [CiNii Books] [Othres link]
• バイオルミネッセンス化学の基礎と展開（特集／ルミネッセンス化学の最前線）
• The reaction mechanism of calcium-activated photoprotein bioluminescence [DOI]
• 生物発光の分子メカニズムに学ぶ発光分子素子の設計 [CiNii Research (CiNii Articles)] [CiNii Books] [Othres link]
• ウミホタルとオワンクラゲの生物発光：反応機構研究の新展開
• 分子イメージング最前線～いま注目の論文「生物発光とナノテクの融合－生体内イメージングのための自家発光量子ドット」
• 生物発光分子系を基盤とする機能性色素化学：イミダゾピラジノンπ電子系の基礎化学と応用 [DOI] [CiNii Research (CiNii Articles)] [CiNii Books] [Othres link] [Othres link]
• Luciferin chiral selectivity divides action mode of firefly luciferase: L-selective coenzyme A ligation and D-selective bioluminescence. [DOI]
• 生物発光研究からの分子素子開発の展望（特集／分子エレクトロニクスの展望） [CiNii Research (CiNii Articles)] [CiNii Books] [Othres link]
• 部位特異的変異法 [CiNii Research (CiNii Articles)] [CiNii Books]
• オワンクラゲ生物発光の分子過程-化学発光・生物発光における励起分子生成機構(共著)
• 生物発光と化学発光の分子機構 [DOI]

講演・口頭発表等

• Mechanistic study on the firefly bioluminescence reaction based on photochemistry
• 有機光化学で迫る生物発光と化学発光：ホタルからソフトクリスタルへ
• ソフトクリスタル化学発光系で築く結晶化学反応の学理
• Thermal Reaction-induced Phenomena in Soft Crystals Found with 1,2-Dioxetane Chemiluminescence [Othres link]
• A Soft-Crystal Chemiluminescence System: Luminescence Property of Adamantylideneadamantane 1,2-Dioxetanes Conjugated with a Fluorophore [Othres link]
• Study on Soft-Crystal Chemiluminescence, a Solid-State Chemistry to Support Devise Development [Othres link]
• ソフトクリスタル化学発光系による可視化で捉えた結晶内反応の特徴 [Othres link]
• ソフトクリスタル化学発光系の創製：結晶内反応の可視化による評価 [Othres link]
• Recent Advances in Fundamental Chemistry of Bio- and chemiluminescence [Othres link]
• Oxygenation Model Reactions of the Firefly Bioluminescence [Othres link]
• Color Modulation in the Firefly Bioluminescence: Mechanism Elucidation Based on the Fluorescence Property of the Enol-form of Oxyluciferins [Othres link]
• Crystalline-state Chemiluminescence of 1,2-Dioxetanes with an Phenacene Side Chain [Othres link]
• 色素連結型アダマンチリデンアダマンタン系ジオキセタンの結晶状態での化学発光特性の評価 [Othres link]
• アクリジン系1,2-ジオキセタン誘導体の結晶状態での化学発光特性 [Othres link]
• フェナセン側鎖を有する1,2-ジオキセタンの結晶状態での化学発光：エネルギー移動型発光特性の評価 [Othres link]
• ルシフェリン構造改変に基づくホタル生物発光の反応機構解明 [Othres link]
• ホタル発光系の波長制御機構研究：エノール型発光体の蛍光特性評価 [Othres link]
• A Soft Crystal Chemiluminescence System: Chemiluminescence Property of 1,2-Dioxetanes with a Phenacene Side-chain in the Crystalline-state, [Othres link]
• Crystalline-state Chemiluminescence Property of Adamantylideneadamantane 1,2-Dioxetanes with a Conjugated Fluorophore [Othres link]
• Crystalline-state Chemiluminescence Properties of 1,2-Dioxetane Derivatives with a Acridine Moiety [Othres link]
• Seeing Chemical Reactions in Soft Crystals: Crystalline-state Chemiluminescence Properties of 1,2-Dioxetane Derivatives [Othres link]
• ソフトクリスタル化学発光系の創製：ジオキセタン系の固相化学発光
• 反応機構で考える生物・化学発光
• Study on the color modulation mechanism of firefly bioluminescence with an amine substituent effect of luciferin and oxyluciferin [Othres link]
• The Color Modulation Mechanism in Beetle Bioluminescence Based on Photochemical Evaluations of the Luminescent Properties [Othres link]
• Design of Heterocyclic Fluorophores Based on a Bioluminescence Light-emitter [Othres link]
• Characterization of the luciferase active site for the color modulation mechanism in firefly bioluminescence [Othres link]
• Excited singlet states of firefly light-emitter analogs in luciferase supramolecular environments [Othres link]
• ホタル生物発光の化学：基礎と応用の最前線 [Othres link]
• ホタル生物発光の化学：基礎と応用の最前線
• Color modulation mechanism of firefly (beetle) bioluminescence: an organic photochemistry approach with a substituent effect
• A Photochemical Aspect of Color Modulation Mechanism of Firefly (Beetle) Bioluminescence
• ウミホタルルシフェリンアナログの化学発光特性制御
• 発光分析のための生物発光色制御：ホタルの基本原理
• ホタルの仲間の生物発光色制御メカニズム
• 生物発光に学ぶ化学発光の高性能化
• Reaction mechanism of the imidazopyrazinone-bioluminescent system
• Electron-transfer oxygenation mechanism in the imidazopyrazinone bioluminescence
• 生物発光の分子機構：ウミホタルの高性能発光について
• 生物発光の分子メカニズムと発光分子素子の設計指針
• 生物発光に学ぶ色素センサー分子の開発
• 生物発光の分子メカニズムと発光分子素子の設計指針
• Development of the Chemistry of the Imidazopyrazinone-bioluminescence System: From the Bio- and chemiluminescence Mechanism to a Design of Sensor Molecules
• 生物発光に学ぶ発光分子素子の設計指針
• 工業的触媒反応を指向した高選択性パラジウム材料の開発
• ギンコライドＢの全合成研究
• フェニル置換イミダゾピラジノン誘導体のソルバトクロミズム
• イミダゾピラジノン誘導体の金属イオン認識特性
• ギンコライドＢの全合成研究
• 工業的触媒反応を指向した高選択性パラジウム材料の開発
• Development of Hydrogenolysis-free Hydrogenation Selective Pd black Catalyst Deposited on Pd Sheet
• ラチア生物発光の分子機構; 発光反応生成物の構造解析
• 電極反応を用いたスチリルオレフィン選択的酸化開裂反応
• ＦＡＤおよび,ＦＭＮおよびリボフラビンのＭＡＬＤＩ,ＦＡＢおよびＥＳＩスペクトル：生体における酸化還元との類似性
• Mass Spectrometric Characterization of FAD, FMN and Riboflavin: Analogy to the Biological Redox Reaction
• ラチアルシフェラーゼの生成とその性質
• マススペクトロメトリーにおけるＦＡＤおよび関連化合物の２段階１電子還元反応
• エクオリン生物発光におけるエミッターの構造決定：セレンテラミドフェノレートアニオンの蛍光特性
• ギンコライドＢの全合成研究
• 水素添加反応を選択的に行うパラジウム触媒の開発
• パラジウム触媒を用いた，選択的水素添加反応の開発
• ラチア生物発光の分子基盤
• 発光貝ラチアルシフェラーゼの精製と活性発現について：第73回日本生化学大会（横浜）
• エクオリン生物発光におけるエミッターの蛍光特性
• 新しいソルバトクロミズム色素：２-フェニルイミダゾピラジノン誘導体の吸収・蛍光特性
• 発光巻き貝ラチア生物発光の分子基盤研究
• 光照射下電極反応を用いたイソイタリセンの合成
• 電解によるアルケン類の選択的水素添加反応の開発
• ギンコライドＢの全合成研究
• ラチア発光系におけるルシフェラーゼの構造と発光活性
• マススペクトロメトリーによるラチアルシフェラーゼの構造解析
• エクオリン生物発光におけるエミッターの蛍光特性
• 化学発光性を有するイミダゾピラジノン誘導体の基本物性
• Supramolecular Interaction in Aequorin Bioluminescence
• エクオリン生物発光における超分子化学：分子認識特性
• 光誘起電子移動反応を用いたヘテロ環化合物の合成
• ラチア生物発光におけるルシフェリンの構造活性相関
• ラチア発光系に関与する蛍光性蛋白質の構造
• ピクロトキシン誘導体の調製
• 光照射下電極反応を用いたイタリセンの合成
• ジメチルグロイオシフォンAの合成
• 光誘起電子移動反応を用いた多環性化合物の合成
• 光誘起電子移動反応を用いたヘテロ環性化合物の合成

書籍等出版物

• Soft Crystals - Flexible Response Systems with High Structural Order (The Materials Research Society Series) [Othres link]
• CSJ Current Review 36, 「生体分子反応を制御する－化学的手法による機構と反応場の解明」
• 光化学フロンティア－未来材料を生む有機光化学の基礎
• 光と生命の事典
• 有機合成実験法ハンドブック 第2版
• 光化学の事典
• Proceedings of the 15th International Symposium on Bioluminescence and Chemiluminescence: Light Emission: Biology and Scientific Applications
• Proceedings of the 14th International Symposium on Bioluminescence and Chemiluminescence: Chemistry, Biology and Applications
• Bioluminescence & Chemiluminescence Progress and Perspectives
• Bioluminescence & Chemiluminescence Progeress and Perspectives
• 生物発光・化学発光の分子過程／季刊化学総説「光化学の基礎と最先端研究」

作品等

共同研究・競争的資金等の研究課題

• ソフトクリスタル化学発光系の創製と刺激応答機能の時空間制御
• 生物発光における鍵反応過程の分子機構と高性能化要因の解明
• ホタル生物発光系をモデルとした人工発光系の創出
• ヤコウタケ生物発光機構解明と標識材料の開発研究
• 未利用生物発光システムおよび新規蛍光タンパク資源の探索と生体分子プローブ化
• 新規ルシフェリンを構造基盤とする新機軸発光性・蛍光性光機能物質の開発
• 発光巻き貝ラチア生物発光の分子基盤研究
• GFP蛍光発色団を分子基盤とするON/OFFモード蛍光バイオセンサーの開発
• 工業化を指向した,原子状水素を用いる選択的水素添加反応の開発
• イオン感応性を有する生物・化学発光系の発光反応機構の解明
• 新規生物発光系と発光行動に関わる分子基盤研究
• 発光蛋白質エクオリン生物発光における超分子構造
• イミダゾピラジン化学発光系における励起分子生成機構の解明と発光能の制御
• 発光蛋白質エクオリン生物発光における超分子構造
• イミダゾピラジン化学発光系の励起分子生成機構の解明
• 発光蛋白質エクオリンの生物発光における超分子構造のダイナミクス
• 生体情報伝達物質の質量分析学的研究

メディア報道

産業財産権

• 新規セレンテラジン誘導体
• 蛍光色素
• ビスイミダゾピラジノン誘導体及びビスアミノピラジン誘導体並びに化学発光物質
• ビスイミダゾピラジノン誘導体及びビスアミノピラジン誘導体
• [アシルアミノピラジナト-Ｏ，Ｎ]ボロン誘導体及び蛍光色素
• 複素環化合物及び発光方法
• 複素環化合物及び発光甲虫ルシフェラーゼ発光系用発光基質
• 芳香族有機化合物の分解方法

所属学協会

• 電気化学会
• 生物発光化学発光研究会
• 基礎有機化学会
• アメリカ光生物学会
• アメリカ化学会
• 有機合成化学協会
• 光化学協会
• 日本化学会

委員歴

担当経験のある科目

• 実践的先進機器分析
• 化学生命工学実験第二
• 高分子有機化学
• 機器分析学
• 基盤理工学専攻基礎
• 化学概論第一
• 輪講A
• 光化学
• 基礎科学実験Ｂ
• 現代化学
• 総合コミュニケーション科学
• 2021先端科学技術総論
• 世界教養プログラム：現代社会の諸問題において顕在化する科学技術
• 特別講義Ⅰ「化学生物学特論」
• 高分子機能科学
• 化学特別講義III
• 有機化学
• 生体機能システム実験第二
• 物質・生命理工学特別講義 生物発光化学特論
• 先進理工学基礎
• 化学概論
• 移動現象論
• キャリア教育演習
• 高分子材料科学
• 有機化学II
• 物質・生命情報工学実験Ｂ
• 材料分析特論
• 化学構造論
• 化学結合と構造
• 化学実験
• 電子材料工学実験I&II

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