学位

• 理学博士(大阪大学)
• ()

経歴

学歴

受賞

• Outstanding Reviewer
• 日本神経科学学会奨励賞

その他

論文

• SARM1 is essential for NMDA receptor-dependent endocytosis of AMPA receptors in hippocampal neurons. [DOI] [PubMed]
• Activation of innate immune receptor TLR9 by mitochondrial DNA plays essential roles in the chemical long-term depression of hippocampal neurons [DOI] [ResearchMap]
• Subunit-dependent and subunit-independent rules of AMPA receptor trafficking during chemical long-term depression in hippocampal neurons
• PIP3-Phldb2 is crucial for LTP regulating synaptic NMDA and AMPA receptor density and PSD95 turnover
• PhotonSABER: new tool shedding light on endocytosis and learning mechanisms in vivo. [DOI] [PubMed] [PubMed Central]
• エンドサイトーシスを制御する新しい技術により明らかにされた小脳における長期抑圧と運動学習との因果関係 [DOI]
• Optogenetic Control of Synaptic AMPA Receptor Endocytosis Reveals Roles of LTD in Motor Learning. [DOI] [PubMed]
• Chemical labelling for visualizing native AMPA receptors in live neurons [DOI] [Web of Scientce]
• AP-4 [DOI]
• Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis [DOI] [Web of Scientce]
• Stargazin regulates AMPA receptor trafficking through adaptor protein complexes during long-term depression [DOI] [Web of Scientce]
• The delta 2 glutamate receptor gates long-term depression by coordinating interactions between two AMPA receptor phosphorylation sites [DOI] [Web of Scientce]
• NMDA Receptor-Mediated PIP5K Activation to Produce PI(4,5)P-2 Is Essential for AMPA Receptor Endocytosis during LTD [DOI] [Web of Scientce]
• D-Serine regulates cerebellar LTD and motor coordination through the delta 2 glutamate receptor [DOI] [Web of Scientce]
• Cerebellar long-term depression requires dephosphorylation of TARP in Purkinje cells.
• 小脳長期抑制とTARPによる制御(Cerebellar LTD and regulation by TARPs)
• 細胞内輸送と代謝 AP-4欠損神経細胞軸索におけるAMPA受容体のオートファゴソームへの集積
• Cbln1 binds to specific postsynaptic sites at parallel fiber-Purkinje cell synapses in the cerebellum [DOI] [Web of Scientce]
• Polarized sorting of AMPA receptors to the somatodendritic domain is regulated by adaptor protein AP-4.
• AP-4: Autophagy-four mislocalized proteins in axons [DOI] [PubMed]
• Accumulation of AMPA receptors in autophagosomes in neuronal axons lacking adaptor protein AP-4 [DOI] [Web of Scientce]
• Mechanisms for polarized sorting of glutamate receptors to the somatodendritic domain of neurons [Web of Scientce]
• The extreme C-terminus of GluR delta 2 is essential for induction of long-term depression in cerebellar slices [DOI] [Web of Scientce]
• Characterization of the delta 2 glutamate receptor-binding protein delphilin - Splicing variants with differential palmitoylation and an additional PDZ domain [DOI] [Web of Scientce]
• A new motif necessary and sufficient for stable localization of the delta 2 glutamate receptors at postsynaptic spines [DOI] [Web of Scientce]
• Roles of the N-terminal domain on the function and quaternary structure of the ionotropic glutamate receptor [DOI] [Web of Scientce]
• Rescue of abnormal phenotypes of the delta 2 glutamate receptor-null mice by mutant delta 2 transgenes [DOI] [Web of Scientce]
• The C-terminal juxtamembrane region of the delta 2 glutamate receptor controls its export from the endoplasmic reticulum [DOI] [Web of Scientce]
• A hot spot for hotfoot mutations in the gene encoding the delta 2 glutamate receptor [DOI] [Web of Scientce]
• Heteromer formation of delta 2 glutamate receptors with AMPA or kainate receptors [Web of Scientce]
• Mutation in hotfoot-4J mice results in retention of delta 2 glutamate receptors in ER [DOI] [Web of Scientce]
• Cloning and characterization of a novel NMDA receptor subunit NR3B: a dominant subunit that reduces calcium permeability. [CiNii Research (CiNii Articles)]
• Disruption of AMPA receptor GluR2 clusters following long-term depression induction in cerebellar Purkinje neurons [Web of Scientce]
• Phosphorylation of serine-880 in GluR2 by protein kinase C prevents its C terminus from binding with glutamate receptor-interacting protein [Web of Scientce]
• Interaction of the C-terminal domain of delta glutamate receptor with spectrin in the dendritic spines of cultured Purkinje cells [Web of Scientce]
• The clustering of NMDA receptor NR1 subunit is regulated by the interaction between the C-terminal exon cassettes and the cytoskeleton [Web of Scientce]
• Role of carboxyl-terminal charges on S-modulin membrane affinity and inhibition of rhodopsin phosphorylation [Web of Scientce]
• Evolution of visual pigments and related molecules [PubMed]
• The role of calcium-binding sites in S-modulin function [Web of Scientce]
• A novel subtype of G-protein-coupled receptor kinase, GRK7, in teleost cone photoreceptors [Web of Scientce]
• Functional expression and characterization of frog photoreceptor-specific calcium-binding proteins [Web of Scientce]
• Photoreceptor protein s26, a cone homologue of S-modulin in frog retina [Web of Scientce]

その他業績

• Chemical LTD stimulation induced the drastic mitochondrial morphological changes in cultured hippocampal neurons [ResearchMap]
• Mechanism of hippocampal adult-born neurons for memory consolidation [DOI]
• 【小脳学習説Marr-Albus-Ito理論の50年】小脳学習における長期抑圧(LTD)の役割
• Optogenetic control of the function of the Golgi apparatus in neurons [Web of Scientce]
• Stargazin regulates AMPA receptor trafficking from plasma membrane to early endosome and lysosome during long term depression [Web of Scientce]
• How does the delta 2 glutamate receptor regulate cerebellar LTD? [Web of Scientce]
• Cerebellar LTD and regulation by TARPs [DOI] [Web of Scientce]
• New mechanisms regulating stability and dynamics of AMPA receptors [DOI] [Web of Scientce]
• New mechanisms regulating the number of AMPA receptors at synapses [DOI] [Web of Scientce]
• メンブレントラフィックと神経系 神経における極性輸送--ついに樹状突起特異的輸送の分子機構の一端が明らかに (メンブレントラフィックの奔流--分子から細胞,そして個体へ) -- (メンブレントラフィックと高次機能) [CiNii Research (CiNii Articles)]
• Disruption of AMPA receptor GluR2 clusters following long-term depression induction in cerebellar Purkinje neurons (vol 19, pg 2765, 2000) [Web of Scientce]
• Phosphorylation of serine 880 in GluR2 by protein kinase C prevents its C-terminus binding with the glutamate receptor interacting protein, GR [Web of Scientce]

講演・口頭発表等

• リソソーム開口放出に着目した光遺伝学による長期可塑性の新規制御ツール [ResearchMap]
• Chemical LTD stimulation induced the drastic mitochondrial morphological changes in cultured hippocampal neurons
• シナプス可塑性の光操作－記憶・学習を制御するオプトジェネティクス－
• シナプス可塑性の光操作－記憶・学習を制御するオプトジェネティクス－
• Lysosomal exocytosis controls AMPA receptor trafficking
• MMP-9 activity is required for the NMDA induced endocytosis of AMPA receptor
• New optogenetical tool clarified that the cerebellar LTD was essential for motor learning
• Lysosomal exocytosis is essential for NMDA-induced AMPA receptor exocytosis and LTP in hippocampus
• Optogenetical control of AMPA receptor endocytosis clarified that the cerebellar long term depression directly regulate motor learning
• Development of the optogennetical technique which control the endocytosis of AMPA receptor and the long-term depression
• 小脳長期抑圧の制御技術開発と運動学習メカニズムの解析
• Novel optogenetical technique clarified that the cerebellar LTD was essential for the motor learning
• The interaction between stargazin and synaptotagmin-7 is controlled by both of phosphorylation and Ca2+ concentration.
• AMPA受容体－TARP複合体の細胞内輸送機構
• Understanding and controlling synaptic plasticity
• Molecular mechanism and controlling method for synaptic plasticity
• シナプス可塑性を支えるAMPA受容体の細胞内輸送機構
• Development of the technology for controlling synaptic plasticity
• Stargazin regulates AMPA receptor trafficking from plasma membrane to early endosome and lysosome during long term depression.
• AMPA受容体のエンドサイトーシス制御機構
• New mechanisms regulating the number of AMPA receptors at synapses
• AP-4によるAMPA受容体の極性輸送
• Mechanisms for polarized sorting of glutamate receptors to the somatodendritic domain of neurons
• Mechanisms for Polarized Sorting of Glutamate Receptors to the Somatodendritic Domain of Neurons

書籍等出版物

• CLINICAL NEUROSCIENCE 小脳学習説 Marr-Albus-Ito理論の50年
• 脳科学辞典（アダプタータンパク質複合体）
• スタンフォード神経科学
• 脳科学辞典（長期抑圧）
• 蛋白質核酸酵素増刊 「メンブレントラフィックの奔流」

作品等

共同研究・競争的資金等の研究課題

• Toll様受容体によるシナプス可塑性の制御
• 光操作によるシナプス可塑性と記憶形成の因果関係の解明
• TARPのリン酸化によるAMPA受容体輸送の制御機構
• 小脳をモデルとした糖鎖シグナルによる機能的・形態的シナプス可塑性制御
• 光による細胞内輸送とシナプス可塑性の制御
• 細胞内輸送機構による神経機能の制御
• 神経細胞における樹状突起特異的輸送機構
• 神経細胞間で機能する新しい分泌性C1qファミリー分子群の解析
• 神経細胞樹状突起へのAMPA受容体トランスポートソームの特異的輸送機構
• 神経細胞における極性輸送の分子機構
• 神経細胞における極性輸送を支える新しいトラフィック制御機構
• 成熟脳におけるシナプス維持と記憶の形成-δ2グルタミン酸受容体を介する新しい機構
• 小脳における記憶・学習の新しい分子機構―δ2グルタミン酸受容体の役割
• グルタミン酸受容体の構造解析のための新しい精製法の開発-安定多量体ペプチドの応用
• 神経細胞における受容体の選択的輸送とシナプス可塑性を支えるトラフィック制御機構
• 小脳における記憶・学習の新しい分子機構―δ２グルタミン酸受容体の役割
• AMPA型グルタミン酸受容体のリン酸化による神経細胞の感度調節機構

メディア報道

産業財産権

所属学協会

• 日本小脳学会
• 北米神経科学学会
• 日本神経科学学会
• 日本生理学会

委員歴

担当経験のある科目

• 基盤理工学専攻基礎
• 基盤理工学専攻基礎
• 化学生命工学実験第二
• 化学生命工学実験第二
• UECパスポートセミナー
• UECパスポートセミナー
• 生体情報システム論１
• 生体情報システム論１
• 先進理工学基礎
• 生体機能システム実験第二
• 先進理工学基礎
• 先進理工学基礎
• 生体機能システム実験第二
• 生体機能システム実験第二
• Biology
• Molecular Biology
• 分子生物学
• neurosience
• 神経科学
• 生物学
• 生物学
• Fundamentals of Information Biology
• 生体情報学基礎

社会貢献活動

• 夏休みは電通大でラボ体験2023
• スプリングスクール

学術貢献活動

• 第47回日本神経科学大会プログラム委員
• 博士前期課程入試面接
• 学域一般入試採点(後期試験）
• 先端工学基礎課程面接試験