学位

• 博士 (学術)(東京大学)

経歴

学歴

受賞

その他

論文

• 運動時乳酸代謝の特徴と役割 [DOI] [CiNii Research]
• Time-series transcriptomics reveals distinctive mRNA expression dynamics associated with gene ontology specificity and protein expression in skeletal muscle after electrical stimulation-induced resistance exercise. [DOI] [PubMed]
• In vivo intracellular Ca2+ profiles after eccentric rat muscle contractions: Addressing the mechanistic bases for repeated bout protection. [DOI] [PubMed]
• Eccentric contraction increases hydrogen peroxide levels and alters gene expression through Nox2 in skeletal muscle of male mice [DOI] [Othres link]
• Cmah deficiency blunts cellular senescence in adipose tissues and improves whole-body glucose metabolism in aged mice. [DOI] [PubMed]
• Cooling of male rat skeletal muscle during endurance-like contraction attenuates contraction-induced PGC-1α mRNA expression. [DOI] [PubMed] [PubMed Central]
• In vivo cytosolic H2O2 changes and Ca2+ homeostasis in mouse skeletal muscle. [DOI] [PubMed]
• 高圧高酸素処置が運動後の筋グリコーゲン回復に及ぼす影響
• Chronic repetitive cooling and caffeine-induced intracellular Ca²⁺ elevation differentially impact adaptations in slow- and fast-twitch rat skeletal muscles [DOI] [Othres link]
• Branched-chain amino acid supplementation suppresses the detraining-induced reduction of mitochondrial content in mouse skeletal muscle. [DOI] [PubMed]
• Effect of endurance training and PGC-1α overexpression on calculated lactate production volume during exercise based on blood lactate concentration. [DOI] [PubMed] [PubMed Central]
• Short-Term Calorie Restriction Maintains Plasma Insulin Concentrations along with a Reduction in Hepatic Insulin-Degrading Enzyme Levels in db/db Mice. [DOI] [PubMed] [PubMed Central]
• In vivo Ca2+ dynamics during cooling after eccentric contractions in rat skeletal muscle. [DOI] [PubMed]
• Trans-omic Analysis Reveals ROS-Dependent Pentose Phosphate Pathway Activation after High-Frequency Electrical Stimulation in C2C12 Myotubes. [DOI] [PubMed] [PubMed Central]
• Single-Cell Information Analysis Reveals That Skeletal Muscles Incorporate Cell-to-Cell Variability as Information Not Noise. [DOI] [PubMed]
• Effects of electrical stimulation-induced resistance exercise training on white and brown adipose tissues and plasma meteorin-like concentration in rats. [DOI] [PubMed] [PubMed Central]
• Effects of acute 3-h swimming exercise on insulin secretion capacity of pancreatic islets [DOI] [Othres link]
• Monitoring and mathematical modeling of mitochondrial ATP in myotubes at single-cell level reveals two distinct population with different kinetics. [DOI] [DBLP] [Othres link]
• Effects of clenbuterol administration on mitochondrial morphology and its regulatory proteins in rat skeletal muscle. [DOI] [PubMed] [Othres link] [Othres link]
• Effects of low-carbohydrate diet and resistance exercise training on physical characteristics and concentrations of plasma metabolites and hormones [DOI] [Othres link]
• 低糖質食事法およびレジスタンス運動が身体組成と血中代謝物・ホルモン濃度に与える影響 [Othres link] [Othres link]
• Accumulation of intramyocyte TRPV1-mediated calcium during heat stress is inhibited by concomitant muscle contractions. [DOI] [PubMed]
• Automatic Quantitative Segmentation of Myotubes Reveals Single-cell Dynamics of S6 Kinase Activation. [DOI] [PubMed]
• Selective control of up-regulated and down-regulated genes by temporal patterns and doses of insulin [DOI] [PubMed] [Web of Scientce]
• Exercise-induced expression of monocarboxylate transporter 2 in the cerebellum and its contribution to motor performance [DOI] [PubMed] [Web of Scientce]
• High-intensity interval training enhances oxidative capacity and substrate availability in skeletal muscle [DOI] [CiNii Research (CiNii Articles)] [CiNii Books]
• Effects of decreased lactate accumulation after dichloroacetate administration on exercise training-induced mitochondrial adaptations in mouse skeletal muscle. [DOI] [PubMed] [PubMed Central]
• Daily heat stress treatment rescues denervation-activated mitochondrial clearance and atrophy in skeletal muscle [DOI] [PubMed] [Web of Scientce]
• Pre-exercise casein peptide supplementation enhances endurance training-induced mitochondrial enzyme activity in slow twitch muscle, but not fast twitch muscle of high fat diet-fed mice [DOI] [CiNii Research (CiNii Articles)]
• Chronic Post-Exercise Lactate Administration with Endurance Training Increases Glycogen Concentration and Monocarboxylate Transporter 1 Protein in Mouse White Muscle [DOI] [PubMed] [Web of Scientce]
• Postexercise whole body heat stress additively enhances endurance training-induced mitochondrial adaptations in mouse skeletal muscle [DOI] [PubMed] [Web of Scientce]
• High-intensity interval training increases intrinsic rates of mitochondrial fatty acid oxidation in rat red and white skeletal muscle [DOI] [PubMed]
• Monocarboxylate transporter and lactate metabolism [DOI] [CiNii Research (CiNii Articles)] [CiNii Books]
• Clenbuterol, a β2-adrenergic agonist, reciprocally alters PGC-1 alpha and RIP140 and reduces fatty acid and pyruvate oxidation in rat skeletal muscle. [DOI] [PubMed] [Web of Scientce]
• Effect of growth on monocarboxylate transporters and indicators of energy metabolism in the gluteus medius muscle of Thoroughbreds [CiNii Research (CiNii Articles)] [DOI] [PubMed] [Web of Scientce]
• Higher Lactate Transporter Protein and Citrate Synthase Activity Following Short-term High-intensity Repetition Training in Mice [DOI] [CiNii Research (CiNii Articles)]
• Effects of high-intensity training on monocarboxylate transporters in Thoroughbred horses [DOI]

その他業績

• ラット骨格筋におけるレジスタンス運動後のmRNA発現量変動とタンパク質発現量の関係 [J-GLOBAL]
• 老齢マウス骨格筋におけるヒト特異的CMAH遺伝子欠損の影響 [J-GLOBAL]
• 4週間の高脂肪食摂取は筋収縮による遺伝子発現に影響を与える [J-GLOBAL]
• ピルビン酸投与は高脂肪食摂取による糖代謝異常を改善させる [J-GLOBAL]
• 豊かな環境における自発性身体活動量と海馬における発現変動遺伝子の関係 [J-GLOBAL]
• Single-cell information analysis reveals small intra- and large intercellular variations increase cellular information capacity
• B-1-3 Heat stress treatment rescues denervation-induced mitochondrial loss in skeletal muscle(The Proceedings of the 23rd Annual Meetings of Japan Society of Exercise and Sports Physiology July 25・26, (Tokyo)) : [CiNii Research (CiNii Articles)] [CiNii Books] [Othres link] [Othres link] [Othres link]
• High-intensity interval training increases the rate of mitochondrial fatty acid oxidation in rat skeletal muscle [CiNii Research (CiNii Articles)] [CiNii Books] [Othres link]
• カゼインペプチドの長期摂取がエネルギー代謝に及ぼす影響 [J-GLOBAL]
• 2-A-09 Single oral taurine supplementation activates muscleglycogen resynthesis during period of recovery from exhaustive exercise(The Proceedings of the 19th Annual Meetings of Japan Society of Exercise and Sports Physiology August 25・26, (Tokushima)) : [CiNii Research (CiNii Articles)] [CiNii Books] [Othres link] [Othres link]
• 2-A-08 Changes in protein contents of PGC-1α and RIP140 and metabolic adaptation after three weeks of clenbuterol administration(The Proceedings of the 19th Annual Meetings of Japan Society of Exercise and Sports Physiology August 25・26, (Tokushima)) : [CiNii Research (CiNii Articles)] [CiNii Books] [Othres link] [Othres link]
• 265. サラブレッドにおける発育発達によるMCTタンパク質量の変化(代謝,一般口演,第63回日本体力医学会大会) [CiNii Research (CiNii Articles)]
• 273. ビタミンB1誘導体の投与が、安静時及び持久的運動時における糖代謝に与える影響(代謝,一般口演,第63回日本体力医学会大会) [CiNii Research (CiNii Articles)] [CiNii Books] [医中誌Web]
• 244. 高強度のレペティショントレーニングは糖の利用を増加させる(代謝,一般口演,第63回日本体力医学会大会) [CiNii Research (CiNii Articles)]
• 194. 3週間の高強度トレーニングがマウスの乳酸代謝に与える影響(代謝,第62回日本体力医学会大会) [CiNii Research (CiNii Articles)] [CiNii Books] [医中誌Web]
• 206. 乳酸の長期投与が運動中の乳酸を中心とする糖代謝に及ぼす影響(代謝,第62回日本体力医学会大会) [CiNii Research (CiNii Articles)]
• 207. フルスルチアミン投与が持久的運動における乳酸を中心とする糖代謝に与える影響(代謝,第62回日本体力医学会大会) [CiNii Research (CiNii Articles)] [CiNii Books] [医中誌Web]
• 208. サラブレッドの各組織におけるMCTタンパク質の分布(代謝,第62回日本体力医学会大会) [CiNii Research (CiNii Articles)]
• 3. Effect of one week of high intensity training on lactate metabolism in mice(The Proceedings of the 15th Annual Meetings of Japan Society of Exercise and Sports Physiology July 26-27, (Hirosaki)) : [CiNii Research (CiNii Articles)] [CiNii Books] [Othres link] [Othres link] [Othres link]
• 6. Effect of TTFD administration on glucose and lactate metabolism in mice during high intensity exercise(The Proceedings of the 15th Annual Meetings of Japan Society of Exercise and Sports Physiology July 26-27, (Hirosaki)) : [CiNii Research (CiNii Articles)] [CiNii Books] [Othres link] [Othres link] [Othres link]

講演・口頭発表等

書籍等出版物

作品等

共同研究・競争的資金等の研究課題

• 乳酸が骨格筋の適応を引き起こす新たな基盤創出とその応用
• 乳酸による適応のメカニズム解明とその応用
• 持久的運動効果の減弱化のメカニズム解明とその解決策
• ドーピング禁止薬物の投与による代謝的適応にエピジェネティクスな制御は関わるか
• 乳酸による骨格筋ミトコンドリア新生のメカニズムの解明
• 骨格筋の適応を引き起こす筋収縮の時間と強度の最適パターンの解明
• 運動における小脳の乳酸輸送単体monocarboxylate transporter2(MCT2)の役割の解明
• 乳酸がミトコンドリア増殖のシグナルとなる可能性の検討

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